bioactive compounds – Page 10

Fruiting body-associated Pseudomonas contact triggers ROS-mediated perylenequinone biosynthesis in Shiraia mycelium culture

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Scientists discovered that bacteria living inside medicinal mushroom fruiting bodies can trigger the production of powerful healing compounds called perylenequinones through direct physical contact. These compounds are being used to fight cancer and harmful bacteria through a therapy called photodynamic therapy. The study shows that when bacteria touch the mushroom’s cells, it causes the mushroom to produce more of these therapeutic compounds by creating controlled stress that activates specific genes.

Xenorhabdus spp.: An Overview of the Useful Facets of Mutualistic Bacteria of Entomopathogenic Nematodes

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Xenorhabdus bacteria are tiny organisms that naturally live inside microscopic worms used for pest control. These bacteria produce powerful substances that can kill harmful insects, fungi, and plant-damaging worms without using toxic chemical pesticides. Scientists are discovering new types of these bacteria and their compounds, which could help create safer products for farming and disease control. This research shows these beneficial microbes could replace harmful chemicals in agriculture.

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

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This comprehensive review explores how traditional healing practices from around the world use plants and mushrooms to treat cancer. The authors examine thousands of plant species and their active compounds that show promise in fighting various types of cancer through multiple mechanisms like stopping cancer cell growth and triggering cell death. The review emphasizes that proper scientific validation, standardization, and safety testing can help integrate these traditional remedies into modern cancer treatment alongside conventional chemotherapy.

Diversity and functions of fungal VOCs with special reference to the multiple bioactivities of the mushroom alcohol

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Fungi release various volatile compounds (VOCs) that have different effects on organisms and the environment. The most notable fungal VOC is 1-octen-3-ol, also called mushroom alcohol, which gives mushrooms their distinctive smell. This compound can inhibit fungal growth, repel insects, and help control plant diseases, but at high concentrations it may be toxic to humans and trigger immune responses. Scientists use fruit flies as a model to study how these fungal compounds affect health.

Burst agitation rate promotes sustained semicontinuous cultivation of filamentous fungi in stirred tank reactors

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Scientists improved the way shiitake mushrooms are grown in fermentation tanks by using a smart agitation strategy. Instead of constant stirring, they used periodic bursts of high-speed mixing to prevent clumping while maintaining healthy fungal growth. This approach increased the amount of usable biomass produced and allowed the fermentation to run longer without interruption, making mushroom cultivation more efficient and sustainable.

Potential Usage of Edible Mushrooms and Their Residues to Retrieve Valuable Supplies for Industrial Applications

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Edible mushrooms are not only nutritious foods but also contain valuable compounds that are being wasted during production. Scientists are discovering new ways to use mushroom waste to make useful products like natural skincare items, water purification materials, and food additives. These innovations help reduce environmental pollution while creating valuable products, supporting a more sustainable circular economy.

Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast

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Scientists successfully engineered baker’s yeast to produce ganoderic acids, potent anti-cancer compounds from medicinal mushrooms, at much higher levels than found in farmed mushrooms. By identifying key enzymes responsible for converting simpler compounds into active ganoderic acids, researchers created yeast strains that produce these valuable compounds 100-10,000 times more efficiently than traditional mushroom farming. This breakthrough could make these expensive medicinal compounds more accessible and affordable for medical research and potential drug development.

Endophytic Fungi Isolated from the Marine Macroalga Dictyopteris pacifica in Korea

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Researchers in Korea discovered three species of fungi living inside a brown seaweed called Dictyopteris pacifica. These fungi were previously unknown in Korea and were identified using genetic analysis. The fungi have mutualistic relationships with the seaweed and may produce compounds useful for medicines and treating diseases.

Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides

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Researchers discovered five potent anti-cancer compounds from Arctic fungi called Acremonium strains. Using advanced chemical analysis techniques, they identified and tested these cyclic depsipeptides against various cancer cell types. The most active compound showed promising results against breast cancer and melanoma cells with extremely low concentrations needed for effect. These findings suggest Arctic microorganisms could be valuable sources for developing new cancer treatments.

Modern Pro-Health Applications of Medicinal Mushrooms: Insights into the Polyporaceae Family, with a Focus on Cerrena unicolor

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This research explores how medicinal mushrooms, especially a species called Cerrena unicolor, could be used to improve human health through functional foods and dietary supplements. These mushrooms contain natural compounds that fight cancer, bacteria, viruses, and free radicals that damage our cells. Scientists have found that incorporating these mushroom extracts into foods, particularly dairy products, could create powerful health-promoting foods that help with cancer treatment, diabetes management, and wound healing.

Research Keyword: bioactive compounds