Research Keyword: bioactive compound screening

Thin-Layer Chromatography (TLC) in the Screening of Botanicals–Its Versatile Potential and Selected Applications

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This review shows how thin-layer chromatography (TLC), a simple laboratory technique, is invaluable for analyzing plant materials. TLC helps scientists identify which plants are related to each other, find beneficial compounds in herbs, ensure herbal medicines are pure and safe, and track illegal psychoactive plants. Despite being less glamorous than modern equipment, TLC remains practical, affordable, and effective for everyday botanical analysis.

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Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23

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Scientists discovered two new antimicrobial compounds called pyrrolomycins from bacteria living in termites using genome sequencing and chemical analysis. These compounds contain chlorine atoms and are related to known antibiotics. The research shows how the bacteria protects itself from its own antimicrobial compounds through chemical modifications, offering insights into developing new antibiotics.

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Screening of Basidiomycete Strains Capable of Synthesizing Antibacterial and Antifungal Metabolites

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Researchers tested 18 types of medicinal mushrooms to see if they could produce natural antibiotics. Most of them (16 out of 18) showed antimicrobial properties, with some being particularly effective against dangerous bacteria and fungi. The most promising mushroom strain (Hericium corraloides 4) showed strong activity against multiple disease-causing organisms. This research suggests that mushrooms could be valuable sources for developing new antibiotics to fight drug-resistant infections.

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