Research Keyword: Bcl-2

Lentinan inhibits melanoma development by regulating the AKT/Nur77/Bcl-2 signaling axis

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This research demonstrates that lentinan, a compound from shiitake mushrooms, can effectively inhibit melanoma (a dangerous skin cancer) in laboratory studies. The compound works by triggering cancer cells to self-destruct through a specific cellular pathway involving three key proteins: AKT, Nur77, and Bcl-2. Importantly, the treatment showed no significant toxic side effects in animal models, suggesting it could be developed as a new cancer therapy option.

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Mycochemistry, antioxidant activity and anticancer potentiality of ethyl acetate extract of Daldinia eschscholtzii against A549 lung cancer cell line

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Researchers studied a wild fungus called Daldinia eschscholtzii to see if it could fight lung cancer. They found that an extract from this fungus contained 28 different beneficial compounds and was effective at killing cancer cells by triggering a process called apoptosis (programmed cell death). The treatment also reduced the cancer cells’ ability to spread, and it appeared safe for normal, healthy cells. Several compounds in the extract showed promise as potential anti-cancer drugs.

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