autophagy – mycolab.ai

Ganoapplanilactone C from Ganoderma applanatum Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish

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Researchers found that a compound called ganoapplanilactone C from the medicinal mushroom Ganoderma applanatum can protect the liver from fat accumulation and damage caused by high-fat diets. In zebrafish studies, this compound worked better than a common cholesterol drug at reducing liver fat and improving liver health. The compound appears to work by activating a protein called AMPK that helps regulate how the body processes fats and reduces inflammation.

Fungal Bioactive Compounds as Emerging Therapeutic Options for Age-Related Neurodegenerative Disorders

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Mushrooms contain special compounds that may help protect our brains as we age. These fungal compounds fight inflammation, reduce harmful free radicals, and help clear out damaged cellular parts—all things that slow down brain aging and diseases like Alzheimer’s and Parkinson’s. While the research looks very promising in lab and animal studies, scientists still need to figure out how to make these compounds work better in the human body and prove they’re safe and effective in patients.

Morphodynamics of non-canonical autophagic structures in Neurospora crassa

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When Neurospora crassa cells run out of carbon, they activate recycling systems to break down and reuse their own cellular components. Unlike yeast, Neurospora creates special bag-like structures called phagophores that form from the cell membrane itself rather than inside the cell. These structures can digest their contents on their own and come in surprising shapes, including doubled structures with four layers of membrane.

Regulation of Oomycete Autophagy, Lipid Droplet Accumulation and Pathogenesis by Three Rab GTPases

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This research investigates three protein molecules called Rab GTPases that control important cellular processes in a disease-causing organism called Peronophythora litchii, which damages litchi fruit crops. Scientists used modern gene-editing technology to remove these proteins and discovered they regulate how the pathogen grows, reproduces through spores, handles stress, and causes disease. The findings suggest these Rab proteins could be targeted to develop new strategies for controlling litchi downy blight and related plant diseases.

Targeting the AMP-activated protein kinase pathway: the active metabolites of botanical drugs represent potential strategies for treating metabolic-associated fatty liver disease

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Fatty liver disease is becoming increasingly common and current medications have side effects like dangerously low blood sugar. This review shows that natural plant-based compounds and traditional Chinese herbs can activate a key protein (AMPK) in the body that helps burn fat and regulate sugar levels. Over 30 different plant compounds from foods and herbs like ginger, curcumin, and ganoderma mushrooms have been shown to improve fatty liver disease by activating this protein through multiple beneficial mechanisms.

Impact of Hericium erinaceus and Ganoderma lucidum metabolites on AhR activation in neuronal HT-22 cells

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This study examined how two medicinal mushrooms, lion’s mane and Reishi, affect nerve cells in the brain. The researchers found that metabolites from these mushrooms don’t harm brain cells and actually boost protective proteins that support cell health and survival. The mushrooms appear to work through a cellular receptor called AhR, which helps facilitate communication between the gut and the brain. These findings suggest that these mushrooms may help support brain function and protect against neurological problems.

The phenol-2-monooxygenase FgPhm1 regulates DON synthesis, pathogenicity and environmental stress response in Fusarium graminearum

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Researchers studied a fungal protein called FgPhm1 in a wheat-infecting fungus that produces harmful toxins called DON. By deleting this gene, they found that the fungus became unable to infect plants and produce toxins, making it less dangerous. The protein also helps the fungus handle stress conditions, and removing it makes the fungus sensitive to oxidative stress while paradoxically tolerant to phenol.

Retromer Regulates Macro- and Micro-Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus

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Rice blast disease causes significant crop damage worldwide. This research reveals how a cellular transport system called the retromer complex helps the fungus Magnaporthe oryzae develop and infect plants by delivering cleaning enzymes to the fungal cell’s digestive compartment. By understanding how these enzymes are transported and used, scientists have identified potential targets for developing better ways to control and prevent rice blast disease.

Autophagy and the Mitochondrial Lon1 Protease Are Necessary for Botrytis cinerea Heat Adaptation

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Scientists studied how a fungus that causes gray mold disease adapts to heat stress by examining two key cellular processes: autophagy (cellular cleanup) and a mitochondrial protease called Lon1. They found that both processes work together to help the fungus survive high temperatures by removing damaged cellular components and maintaining healthy mitochondria. When either process was disrupted, the fungus became much more vulnerable to heat and could not survive as well.

Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review

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Spinocerebellar ataxia type 3 is a serious brain disease that causes movement problems and gets worse over time. Current medications help but often have unpleasant side effects. This review examined fifteen traditional Chinese herbal remedies that show promise in protecting nerve cells from damage caused by oxidative stress, a harmful chemical process in the body. These herbs work through multiple protective mechanisms and may eventually be tested in patients.

Research Keyword: autophagy