Research Keyword: Aspergillus terreus

Aspergillus terreus sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism

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This study investigated why some strains of the fungus Aspergillus terreus are resistant to amphotericin B, an important antifungal medicine. Researchers compared a resistant strain with a mutated version that became susceptible to the drug. They found that certain genes called P-type ATPases are more active in resistant strains and may help the fungus pump ions and alter its cell membrane to survive the drug. Additionally, mutations in genes responsible for producing secondary metabolites were linked to the visible changes seen when fungal cultures degenerate.

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Diversity and bioprospecting activities of endophytic Fungi associated with different Egyptian medicinal plants

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Scientists studied fungi that live inside Egyptian medicinal plants and found that one type called Aspergillus terreus produces compounds with powerful healing properties. These compounds can fight harmful bacteria, reduce oxidative damage, and even kill cancer cells while being safe for normal cells. This discovery suggests that fungi living in medicinal plants could be valuable sources of new medicines, offering hope for developing new treatments for infections and cancer.

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Aspergillus terreus sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism

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When Aspergillus terreus fungi are grown in laboratory conditions for extended periods, they sometimes undergo changes that make them look different and behave differently. Scientists found that these changed strains become more susceptible to amphotericin B, a common antifungal drug. By studying the genes and proteins in both the original and changed strains, researchers discovered that special proteins called P-type ATPases appear to be responsible for the fungus’s natural resistance to this drug, offering new targets for developing better antifungal treatments.

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