Research Keyword: aspergillosis treatment

Aspergillus fumigatus dsRNA virus promotes fungal fitness and pathogenicity in the mammalian host

A virus that infects the fungus Aspergillus fumigatus (which causes serious lung infections in humans) actually makes the fungus more dangerous by improving its ability to survive stress and spread disease. Scientists found that removing this virus from the fungus made infections less severe in mice. They also discovered that antiviral drugs like ribavirin could potentially be used to weaken these virus-infected fungi and improve patient survival.

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Identification of a fungal antibacterial endopeptidase that cleaves peptidoglycan

Scientists discovered a new antibacterial protein called CwhA produced by the fungus Aspergillus fumigatus that acts like molecular scissors, cutting apart the cell walls of harmful bacteria like Staphylococcus aureus. This protein is produced by the fungus when it encounters bacteria in the lungs during infection and helps the fungus fight off bacterial competitors. When CwhA cuts up bacterial cell walls, it creates fragments that alert the immune system, potentially boosting the body’s defense response against infection.

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