Research Keyword: Apoptosis pathways

Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer

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Ganoderma lucidum, a mushroom used in traditional medicine for thousands of years, shows promise in fighting certain blood cancers like leukemia and lymphoma. The mushroom contains special compounds that can kill cancer cells in multiple ways—by triggering cancer cell death, boosting the immune system, and preventing cancer cell growth. While laboratory studies are very encouraging, more testing in humans is needed before it can be used as a standard cancer treatment.

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Chaga mushroom triterpenoids as adjuncts to minimally invasive cancer therapies: A review

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Chaga mushroom, a fungus that grows on birch trees, contains special compounds called triterpenoids that can kill cancer cells in laboratory tests. Some of these compounds, particularly inotodiol and betulinic acid, show anti-cancer activity similar to or better than conventional chemotherapy drugs. While promising, researchers need to improve how these compounds are absorbed in the body and test them more thoroughly in animals and humans before they can be used clinically.

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Kidney Injury Induced by High-Dose Chaga Mushroom Consumption: Experimental Evidence in a Rat Model

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This study examined whether consuming large amounts of Chaga mushroom can damage the kidneys in rats. The researchers found that high-dose Chaga consumption led to kidney injury through accumulation of oxalate (a naturally occurring compound in the mushroom), causing oxidative damage and cell death in kidney tissue. The findings suggest that while Chaga mushroom is promoted as a health supplement, excessive long-term consumption may harm kidney function, particularly in susceptible individuals.

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Medicinal Plants for Chemotherapy-Induced Nausea and Vomiting: A Systematic Review of Antiemetic, Chemosensitizing, and Immunomodulatory Mechanisms

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This review examines how medicinal plants can help manage nausea and vomiting caused by cancer chemotherapy. Over 22 plants including ginger, cannabis, mint, and turmeric work through multiple mechanisms like blocking serotonin pathways and reducing inflammation. Beyond reducing symptoms, these plants may also enhance chemotherapy effectiveness and boost immune function. The research suggests combining medicinal plants with standard cancer treatments could improve patient outcomes and quality of life.

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Potential of Indonesian Herbal as an Anti-Cancer Therapy: A Systemic Review of in vitro Studies

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This review examined eight Indonesian herbal plants that show promise in laboratory studies for fighting various types of cancer. Soursop leaves were the most researched and consistently showed the ability to kill or slow cancer cells in test tubes by triggering natural cell death pathways. The herbs work through bioactive compounds like flavonoids and alkaloids that can interfere with how cancer cells divide and survive. While these results are encouraging, more research is needed to confirm effectiveness in humans.

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