antitumor – mycolab.ai

Fruiting Body Heterogeneity, Dimorphism and Haustorium-like Structure of Naematelia aurantialba (Jin Er Mushroom)

mycolabadmin

Jin Er mushroom, a popular health food in Asia, is actually made up of two different types of fungi growing together. This study discovered that Jin Er can change its form depending on temperature and nutrients, switching between yeast-like and filament-like structures. The research also found special hook-like structures that may help the two fungi interact with each other, which could help improve how Jin Er mushrooms are grown commercially.

Prognostic model for gastric cancer patients with COVID-19 and network pharmacology study on treatment by lentinan

mycolabadmin

This study investigated how lentinan, a compound from shiitake mushrooms, might help treat patients who have both gastric cancer and COVID-19. Researchers identified five genes that predict patient outcomes and found that lentinan may work by controlling immune cell activity and reducing inflammation. The study suggests lentinan could be a useful additional treatment for this challenging combination of diseases, though more research is needed.

Whole genome sequencing and annotations of Trametes sanguinea ZHSJ

mycolabadmin

Scientists have completely mapped the genetic code of Trametes sanguinea, a medicinal mushroom used in traditional Chinese medicine. They identified over 10,000 genes and analyzed how this mushroom produces compounds that fight tumors, boost immunity, protect the heart, and fight viruses. This genetic map will help researchers understand how to produce these beneficial compounds and develop new medicines from this mushroom.

Haplotype-Phased Chromosome-Level Genome Assembly of Floccularia luteovirens Provides Insights into Its Taxonomy, Adaptive Evolution, and Biosynthetic Potential

mycolabadmin

Scientists successfully decoded the complete genetic blueprint of the yellow mushroom (Floccularia luteovirens), a valuable medicinal fungus found on the Tibetan Plateau. The high-quality genome assembly revealed the mushroom produces many different beneficial compounds like antitumor and anti-inflammatory molecules. The study also corrected previous scientific confusion about the mushroom’s evolutionary classification, showing it’s more closely related to other fungi than previously thought, and revealed how it adapted to harsh alpine conditions.

Advances in the extraction, purification, structural characterization, and elucidation of the biological functions of polysaccharides from Hericium erinaceus

mycolabadmin

Hericium erinaceus, commonly known as the monkey head mushroom, contains special molecules called polysaccharides that have numerous health benefits. Researchers have found that these polysaccharides can boost immunity, lower cholesterol and blood sugar, fight tumors, reduce inflammation, and promote healthy gut bacteria. Different extraction methods and purification processes can be used to obtain these beneficial compounds, making them useful for developing health supplements and medicines.

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

mycolabadmin

Scientists studied a medicinal mushroom called Taiwanofungus gaoligongensis to understand how different growing methods affect the production of beneficial compounds. They found that growing the mushroom in special bags with certain wood substrates produced far more of the valuable compounds (up to 12-fold more) compared to growing it on rice medium. By examining which genes were active in different growing conditions, they discovered how the mushroom’s cells control the production of these medicinal compounds, which could help farmers grow more potent medicinal mushrooms.

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

mycolabadmin

This study examined how different growing methods affect the medicinal compounds found in Taiwanofungus gaoligongensis, a rare Chinese medicinal fungus. Researchers discovered that growing this fungus on wood substrates from specific trees significantly increased production of beneficial compounds like antcins and antrodin C, which have anti-cancer and anti-inflammatory properties. By analyzing gene expression patterns, they identified key genes and regulatory mechanisms that control the production of these medicinal compounds, suggesting ways to improve cultivation methods for better medicinal value.

The First Whole Genome Sequence and Methylation Profile of Gerronema lapidescens QL01

mycolabadmin

Scientists have sequenced the complete genome of Lei Wan (Gerronema lapidescens), a medicinal mushroom used in traditional Chinese medicine for treating parasitic infections and digestive problems. The research reveals the mushroom’s genetic blueprint, including genes responsible for producing beneficial compounds and adapting to rocky mountain environments. This foundational work aims to enable sustainable cultivation of this rare fungus and development of new medicinal treatments, addressing current conservation threats from over-harvesting.

Whole-Genome Sequencing and Comparative Genomics Analysis of the Wild Edible Mushroom (Gomphus purpuraceus) Provide Insights into Its Potential Food Application and Artificial Domestication

mycolabadmin

Scientists sequenced the complete genetic code of Gomphus purpuraceus, a wild mushroom eaten in southwest China for hundreds of years. By comparing its genes to other edible mushrooms, researchers discovered it likely forms beneficial partnerships with trees and can break down some plant material. The study shows this mushroom can efficiently use simple sugars like sucrose and maltose for growth, which could help farmers grow it commercially while preserving this rare species.

Revealing the metabolic potential and environmental adaptation of nematophagous fungus, Purpureocillium lilacinum, derived from hadal sediment

mycolabadmin

Scientists discovered a special fungus living in the deepest part of the ocean (Mariana Trench) that can survive extreme pressure and produce compounds with disease-fighting properties. This fungus, Purpureocillium lilacinum, showed promise against bacteria, cancer cells, and parasitic worms. The research revealed how this fungus adapts to survive in one of Earth’s most extreme environments, potentially opening new sources for developing medicines and biological pest control.

Research Keyword: antitumor