antimicrobial resistance – Page 7

First report of Stemphylium lycopersici keratitis, a complex corneal infection case

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A 66-year-old man developed a severe corneal infection from a stone chip injury that didn’t improve with standard antibiotics. Doctors discovered the infection was caused by a rare plant fungus called Stemphylium lycopersici, combined with a herpes virus. Using advanced genetic testing (mNGS) to identify the exact pathogens, they prescribed targeted antifungal and antiviral medications along with a corneal transplant, successfully healing the infection and preserving his vision.

Neonatal Invasive Candidiasis: Current Concepts

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Serious fungal infections (candidiasis) in newborns have become increasingly difficult to treat, especially in developing countries. The types of fungi causing these infections have changed dramatically, with many now resisting the standard fluconazole treatment. Modern medical care, like proper handwashing, environmental cleaning, and careful line care, is actually more effective at preventing these infections than giving preventive antifungal drugs. Healthcare providers need better tools for quickly identifying which fungal species is causing infection and which drugs will work against it.

Design and Evaluation of a Inonotus obliquus–AgNP–Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential

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Researchers studied Chaga mushroom from Romania and developed new ways to package and deliver its beneficial compounds using silver nanoparticles and a food-safe ingredient called maltodextrin. These new delivery systems were designed to work better in the body by improving how well the mushroom’s active ingredients dissolve and stay stable. Testing showed these enhanced formulations were very effective at fighting bacteria, protecting cells from damage, and killing cancer cells.

Identification, characterization, antimicrobial activity and biocontrol potential of four endophytic fungi isolated from Amazonian plants

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Scientists isolated four types of fungi living inside the leaves of medicinal plants from the Amazon region of Bolivia. These fungi produce natural compounds that kill harmful bacteria and fungi that damage potato crops. The findings show promise for developing natural alternatives to synthetic pesticides and antibiotics for agricultural and medical applications.

Advancing Patient Advocacy in Mycology: Cultivating Collaboration in Education, Research, and Policy

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Fungal infections are a serious public health problem, but unlike cancer and AIDS, they lack strong patient advocacy movements to raise awareness and secure funding. This paper argues that patients with fungal diseases have important insights about their care needs that could help improve policies and research if their voices were heard. The authors propose establishing unified advocacy organizations, like the MyCARE Foundation, to bring patients, doctors, and policymakers together to better address this neglected health challenge.

New insights into the stress response mechanisms of stress-resistant Listeria monocytogenes via multi-omics and cell morphological changes

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Researchers studied how a dangerous food-poisoning bacterium called Listeria monocytogenes survives in harsh conditions like cold temperatures, acidic environments, and salty food products. Using advanced molecular analysis techniques, they identified specific genes and proteins that help the bacteria survive these stressful conditions. They also observed that the bacteria changed shape when exposed to stress, becoming elongated and bumpy. This research helps food safety experts better understand and combat this persistent food contaminant.

Five-Year Retrospective Analysis of Superficial Fungal Infections: Insights from Hospital Experience

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This study examined fungal skin infections in over 3,900 patients at a Serbian military hospital over five years. Researchers found that common fungi like Trichophyton mentagrophytes and T. rubrum caused most infections, with patterns varying by season, patient gender, and body location. Men were more likely to have foot infections while women showed more diverse fungal types. The findings suggest doctors should use more precise identification methods like MALDI-TOF testing to prescribe better treatments and help prevent recurring infections.

Environmental sources of Cryptococcus neoformans species complex in Kampala, Uganda: A preliminary study

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Researchers in Uganda identified where dangerous fungal organisms that cause meningitis live in the environment. They tested droppings from birds and chickens, and bark from eucalyptus trees. They found that a harmful fungus called Cryptococcus neoformans was present in marabou stork droppings and eucalyptus tree bark, but not in chicken droppings or another related fungus species called C. gattii. This helps explain why some people in Uganda get cryptococcal meningitis, a serious brain infection.

Research Keyword: antimicrobial resistance