antimicrobial resistance – Page 3

Bioactivity and toxicity of polysaccharides derived from the phytopathogenic mushroom Ganoderma orbiforme cultured in a bioreactor

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Scientists studied a mushroom called Ganoderma orbiforme that normally harms oil palm trees to see if it could be useful as medicine. They grew the mushroom in a special bioreactor and extracted beneficial substances called polysaccharides. These substances showed promise as natural antibiotics and antioxidants while being safe for use based on safety testing with fish embryos.

Green-Synthesized Nanomaterials from Edible and Medicinal Mushrooms: A Sustainable Strategy Against Antimicrobial Resistance

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Scientists are developing a new weapon against antibiotic-resistant bacteria using mushrooms. These special nanoparticles derived from edible and medicinal mushrooms can kill harmful bacteria in multiple ways without the toxic chemicals used in traditional manufacturing. The nanoparticles work by disrupting bacterial membranes, creating harmful molecules called free radicals, and even boosting your body’s natural immune response. This environmentally friendly approach could become an important tool in fighting dangerous infections that don’t respond to current antibiotics.

Isolation and Identification of Endophytic Bacterium B5 from Mentha haplocalyx Briq. and Its Biocontrol Mechanisms Against Alternaria alternata-Induced Tobacco Brown Spot

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Scientists discovered a beneficial bacterium called Bacillus velezensis in mint plants that can fight tobacco brown spot disease caused by a fungus. This bacterium works by producing natural antifungal compounds and enzymes that damage the fungus, and it helps boost the plant’s own defense systems. In greenhouse tests, this bacterial treatment was as effective as commercial chemical fungicides, offering farmers a safer, more environmentally friendly option for protecting their tobacco crops.

New Strategies to Combat Human Fungal Infections

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Fungal infections are becoming a major global health threat, causing millions of deaths annually. This research collection presents new and improved ways to treat these infections, including natural compounds like chitosan, beneficial bacteria, new drug combinations, and tests to better understand which treatments work best. The papers showcase innovative approaches beyond traditional antifungal medications to help combat resistant infections.

Advancing Patient Advocacy in Mycology: Cultivating Collaboration in Education, Research, and Policy

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This paper highlights how patients with fungal infections and their caregivers are rarely included in discussions about healthcare policies and research funding, unlike patients with cancer or HIV. The authors argue that fungal diseases deserve more attention and resources, and that listening to patient experiences is essential for improving how these diseases are prevented, diagnosed, and treated. They propose that dedicated advocacy organizations, like the MyCARE Foundation, can help bridge this gap and ensure fungal infections receive the policy support and research investment they need.

Lack of correlation between in vitro and within patient measures of P. aeruginosa biofilms in cystic fibrosis

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Researchers compared how Pseudomonas aeruginosa bacteria form biofilms (protective clusters) in lung samples from cystic fibrosis patients versus in laboratory culture dishes. They found that the bacteria behave quite differently in the lab compared to in patients’ lungs, suggesting that laboratory tests may not accurately predict how well antibiotics will work in real patients. This highlights the importance of studying bacteria directly from patient samples to better understand how infections actually develop and progress.

Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery

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Scientists developed a fast, automated method called FLECS-96 to screen hundreds of fungal species for antimicrobial compounds in a small 96-well plate format. The method combines fungal culture, chemical extraction, and analysis to identify promising candidates against resistant bacteria like Staphylococcus aureus. The team successfully identified two bioactive compounds from the fungi tested. This innovation could significantly speed up the discovery of new antibiotics to combat antibiotic-resistant infections.

Trichophyton indotineae Infection, São Paulo, Brazil, 2024

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A businessman from São Paulo, Brazil contracted a difficult-to-treat fungal skin infection caused by Trichophyton indotineae, which is resistant to the common antifungal drug terbinafine. After terbinafine failed to help over 9 weeks, doctors switched him to itraconazole, which worked well after 8 weeks. Genetic testing showed his fungal strain had a specific resistance mutation and was most similar to a strain from Germany, suggesting he may have caught it while traveling in Europe.

mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease

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This review examines how serious infections (sepsis) from bacteria and fungi affect people with advanced HIV disease, particularly in hospitals. The infections have become more dangerous due to antimicrobial resistance, and many cases go undiagnosed because of limited laboratory capabilities. The paper calls for better diagnostic tools and treatment strategies tailored to resource-limited settings where most advanced HIV disease cases occur.

Exploring the health benefits of Ganoderma: antimicrobial properties and mechanisms of action

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Ganoderma is a medicinal mushroom that has been used in traditional medicine for thousands of years and is now being studied for its ability to fight infections. The mushroom contains special compounds like polysaccharides and triterpenoids that can kill harmful bacteria and fungi in multiple ways—by breaking down their cell walls, stopping them from reproducing, and boosting your immune system. Scientists have found that Ganoderma works against many dangerous bacteria including antibiotic-resistant strains, and it may offer a natural alternative to conventional antibiotics as antibiotic resistance becomes a major global health problem.

Research Keyword: antimicrobial resistance