Research Keyword: antimicrobial activity

The HOG signal pathway contributes to survival strategies of the piezo-tolerant fungus Aspergillus sydowii DM1 in hadal sediments

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Scientists discovered a special deep-sea fungus from the Mariana Trench (nearly 7 miles deep) and studied how it survives extreme pressure and harsh conditions. By examining its DNA and turning off a specific gene called hog1, they found this gene is crucial for the fungus to handle stress and produce energy. Understanding how this deep-sea fungus adapts could help us develop stronger microorganisms for various applications and better understand how life survives in Earth’s most extreme environments.

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Biology and Application of Chaetomium globosum as a Biocontrol Agent: Current Status and Future Prospects

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Chaetomium globosum is a common soil fungus that shows great potential for protecting crops from diseases and pests naturally. This review explains how it works—by producing toxic compounds against harmful fungi, directly attacking pathogens, and boosting plants’ own defense systems. When applied to seeds or soil, it has reduced crop diseases by up to 73% in field tests while also improving soil health and crop yields, making it a promising alternative to chemical fungicides.

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Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi

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Termite colonies farm a fungus called Termitomyces for food in an ancient partnership. Scientists discovered that the mushrooms produced by this fungus release distinctive chemical signals, particularly a compound called drimenol. By isolating and synthesizing these compounds, researchers found they have antimicrobial properties and may play a role in communicating between termites and their fungal crop or protecting mushrooms from infection.

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Inhibition of RNase to Attenuate Fungal-Manipulated Rhizosphere Microbiome and Diseases

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A fungal pathogen that causes root rot in soybeans and other crops uses a toxic protein called Fg12 to kill beneficial bacteria in the soil that would otherwise protect plants. Scientists discovered that guanosine monophosphate (GMP), a simple chemical compound, can block this toxic protein. When applied to soil, GMP protects plants by allowing beneficial bacteria to survive and fight the fungal infection.

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Bioactivity and chemical screening of endophytic fungi associated with seaweeds Gracilaria sp. and Sargassum sp. of the Bay of Bengal, Bangladesh

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Researchers discovered several types of fungi living inside seaweed from Bangladesh’s Bay of Bengal coast. These fungi produce natural compounds that can fight bacteria, reduce harmful oxidative damage, and potentially kill cancer cells. The study identified specific chemical compounds responsible for these beneficial properties, suggesting these fungi could be useful sources for developing new medicines.

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Lipid Fraction from Agaricus brasiliensis as a Potential Therapeutic Agent for Lethal Sepsis in Mice

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Researchers tested a special extract from the Agaricus brasiliensis mushroom (rich in a compound called ergosterol) to treat severe sepsis, a life-threatening blood infection, in mice. When mice were given this mushroom extract alone, 67% survived, and when combined with antibiotics, 100% survived compared to none with saline alone. The extract reduced inflammation, protected the liver, fought bacteria, and reduced harmful free radicals in the body, suggesting it could be a valuable addition to antibiotic treatment for sepsis.

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