antifungal treatment – Page 5

Favorable outcome of Lasiodiplodia theobromae keratomycosis: a clinical case and systematic review

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A 74-year-old farmer developed a serious fungal eye infection caused by Lasiodiplodia theobromae, a rare tropical fungus. Instead of requiring eye surgery, the patient was successfully treated with a combination of two antifungal medications applied as eye drops and taken orally for eight weeks. This case is significant because it’s the first documented successful medical treatment of this particular fungal infection, highlighting the importance of quick diagnosis and avoiding corticosteroid eye drops that can worsen fungal infections.

Safety and Efficacy of a 48-Month Efinaconazole 10% Solution Treatment/Maintenance Regimen: 24-Month Daily Use Followed by 24-Month Intermittent Use

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Researchers studied a 4-year treatment plan for toenail fungal infections using efinaconazole, an antifungal solution applied daily for 2 years, then 2-3 times weekly for another 2 years. The treatment was safe and effective, with all patients who achieved a cure maintaining it through the maintenance phase, and even some non-cured patients improving further. The study included many elderly patients, showing the treatment is safe across all age groups and could help prevent infection relapse.

First report of Stemphylium lycopersici keratitis, a complex corneal infection case

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A 66-year-old man developed a severe corneal infection from a stone chip injury that didn’t improve with standard antibiotics. Doctors discovered the infection was caused by a rare plant fungus called Stemphylium lycopersici, combined with a herpes virus. Using advanced genetic testing (mNGS) to identify the exact pathogens, they prescribed targeted antifungal and antiviral medications along with a corneal transplant, successfully healing the infection and preserving his vision.

The refractory nailbed ulceration caused by Candida parapsilosis after nail extraction

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An 82-year-old woman developed a stubborn ulcer on her toenail bed after having the nail surgically removed to treat an infected nail fold. Testing revealed the ulcer was caused by a yeast called Candida parapsilosis, which typically causes infections after physical trauma or injury to the skin. Treatment with an antifungal medication called fluconazole successfully healed the ulcer over three months. This is the first reported case of this specific type of infection following nail removal and highlights the importance of properly identifying the cause of chronic nail infections.

Deep cutaneous phaeohyphomycosis caused by Cladophialophora boppii: A case report

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A 69-year-old woman with breast cancer developed a skin infection caused by a rare fungus called Cladophialophora boppii while taking dexamethasone for cancer treatment. Doctors diagnosed the infection through skin biopsy and fungal testing, then removed the infected area surgically. After three weeks of antifungal medication (itraconazole), the infection cleared completely and did not return during four months of follow-up. This case suggests that surgery combined with short-term antifungal treatment may be sufficient for this type of infection.

Combination of Q-switched 1,064 and 532 nm Nd: YAG laser in the treatment of toenail onychomycosis: a pilot study

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This study tested a dual-wavelength laser treatment for toenail fungal infections (onychomycosis) in 15 patients. The laser therapy successfully cured about one-third of patients with mild infections, but was less effective for severe cases. The treatment was safe and well-tolerated, though patients experienced moderate pain during sessions.

PCR enables rapid detection of dermatophytes in practice

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Researchers in Finland studied how a fast DNA test (PCR) can detect fungal skin infections better than traditional slow culture methods. The new test, called DermaGenius, gives results in just 16 hours instead of 19 days. By 2022, most fungal infection samples were tested using this faster method, which helps doctors treat patients quickly without unnecessary medications.

First isolation of Prototheca bovis from a bottlenose dolphin (Tursiops truncatus)

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A 13-year-old bottlenose dolphin at a Japanese aquarium developed a stomach infection caused by Prototheca bovis, a type of alga rarely found in marine animals. The dolphin initially received treatment with itraconazole for a suspected fungal infection, but this was ineffective. When doctors identified the actual culprit as P. bovis through genetic testing, they switched to fos-ravuconazole, which successfully resolved the infection and returned the dolphin to good health.

Application and Mechanism of Action of Carvacrol Against Aspergillus niger Causing Postharvest Rot of Garlic Scapes (Allium sativum L.)

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Garlic scapes, the tender flower stalks of garlic plants, often rot during storage due to fungal infections. Researchers discovered that carvacrol, a natural compound found in herbs like thyme and oregano, effectively kills the fungi responsible for this spoilage. By damaging the fungal cell walls, carvacrol can help preserve fresh garlic scapes longer without synthetic chemicals, making it a promising natural food preservative for grocery stores and consumers.

Usefulness of combining computed tomography and air sac fluid examination to rule out aspergillosis: case study in two gentoo penguins (Pygoscelis papua) with respiratory clinical signs

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Two penguins at an aquarium showed respiratory problems and were suspected of having a serious fungal infection called aspergillosis. Doctors used CT scans to identify fluid in their air sacs and collected samples for testing. The tests showed the penguins did not have the fungal infection, so they did not need antifungal medications. Both penguins recovered naturally, demonstrating that combining imaging with fluid analysis can help identify the real cause of respiratory problems and avoid unnecessary medication.

Research Keyword: antifungal treatment