antifungal therapy – Page 6

Severe Saprochaete capitata fungemia presenting as micafungin breakthrough hepatosplenic lesions in an immunocompromised patient: case report

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A 70-year-old woman with blood cancer developed a serious fungal blood infection caused by Saprochaete capitata, a rare soil fungus, despite taking preventive antifungal medication. The infection spread to her liver and spleen, creating multiple lesions and a dangerous aneurysm. Doctors successfully treated her with a combination of three antifungal drugs, particularly voriconazole, which proved more effective than the initial preventive medication. This case highlights how rare fungi can cause severe infections in cancer patients and the importance of recognizing when standard preventive treatments are not working.

Molecular Mechanisms of Pathogenic Fungal Virulence Regulation by Cell Membrane Phospholipids

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This review explains how the fats that make up fungal cell membranes directly influence how dangerous fungi become to humans. Different types of membrane fats help fungi change shape to invade tissues, survive stress in the body, and hide from immune cells. By understanding these processes, scientists can develop new ways to fight fungal infections by targeting the membrane components that fungi depend on for survival.

Antifungal Effects of Pterostilbene on Candida albicans, Candida dubliniensis, and Microcosm Biofilms of Denture Stomatitis

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Pterostilbene, a natural compound found in blueberries and grapes, has been shown to effectively kill Candida fungi that cause denture-related mouth infections. In laboratory tests, it successfully eliminated fungal cells and disrupted harmful biofilms within 8 hours. When tested in a living organism model, pterostilbene proved safe and reduced infection severity, suggesting it could be a promising natural alternative to conventional antifungal medications.

The dimorphic fungus Talaromyces marneffei: An opportunistic killer in Southeast Asia

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Talaromyces marneffei is a dangerous fungus found in Southeast Asian soil that people inhale, causing a serious disease called talaromycosis. The fungus is particularly deadly for people with weakened immune systems like those with advanced HIV. The fungus has evolved clever tricks to hide from and manipulate the body’s immune system, allowing it to multiply inside immune cells called macrophages.

Pulmonary Mucormycosis in Diabetic Patients: A Case Series From a Tertiary Respiratory Center in Sri Lanka

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This case study describes three diabetic patients in Sri Lanka who developed a serious lung infection caused by a fungus called mucormycosis. The infection caused cavities in the lungs and symptoms like fever, cough, and weight loss. Two patients recovered with antifungal medication (amphotericin B) and surgery, while one patient sadly died despite receiving treatment. The study emphasizes that doctors should consider this infection in diabetic patients with unusual lung symptoms to catch it early.

Efficacy of Rezafungin on Candida albicans Endophthalmitis in a Rabbit Model

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Researchers tested a new antifungal medication called rezafungin to treat a serious eye infection caused by the fungus Candida albicans. Using rabbit models, they found that rezafungin was much more effective than two other antifungal drugs at clearing the infection from the eye and preventing damage to vision. The drug’s ability to work for longer periods with less frequent dosing makes it a promising candidate for treating this devastating infection in patients.

Fungal keratitis complicating the diagnosis of Acanthamoeba keratitis

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A 42-year-old farmer presented with a severe eye infection that was initially misdiagnosed as a viral infection caused by herpes simplex virus. When antiviral treatment failed, doctors discovered the patient had a fungal infection caused by Fusarium. However, advanced testing revealed she actually had a dual infection with both the fungus and a microscopic parasite called Acanthamoeba. The patient required corneal transplant surgery and combination therapy with multiple medications to control the infection and preserve vision.

Identification of fungal agents isolated from burn lesions using mycological and molecular methods in patients admitted to Velayat burn hospital in Rasht city during 2022–2023

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Researchers studied fungal infections in burn patients at a hospital in Iran and found that non-albicans Candida fungi, particularly a species called Candida parapsilosis, were the most common culprits. Using laboratory cultures and genetic testing, they identified 101 fungal infections out of 380 burn patients. Understanding which fungi cause these infections is important for doctors to choose the right treatment and improve patient outcomes.

Disseminated Scytalidium philadelphianum infection in a Belgian Malinois

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A Belgian Malinois dog developed a serious fungal infection caused by Scytalidium philadelphianum, a rare mold, that affected the spine and eventually the brain. The infection was diagnosed through imaging, fluid samples, and fungal culture from the dog’s urine and spine tissue. Despite treatment with multiple antifungal medications over seven months, the dog’s condition worsened with seizures and nerve damage, leading to euthanasia. This case marks the first documented instance of this particular fungal species causing widespread disease in animals.

Cryptococcus: Emerging host risk factors for infection

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This scientific review examines why some people without HIV are getting serious Cryptococcus infections and becoming very sick. Researchers found that people with liver problems, kidney disease, diabetes, cancer, and autoimmune diseases face much higher risk. The review also identifies new drugs and therapies that can surprisingly increase infection risk, highlighting the importance of understanding individual patient factors when treating these dangerous fungal infections.

Research Keyword: antifungal therapy