antifungal therapy – Page 5

Impact of Clove Oil on Biofilm Formation in Candida albicans and Its Effects on Mice with Candida Vaginitis

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Clove oil, a common kitchen spice, shows promise as a treatment for vaginal yeast infections caused by Candida albicans. The oil contains eugenol, which blocks the fungus’s ability to form protective biofilms and reduces inflammation. In mouse studies, clove oil treatment decreased yeast infection symptoms and lowered inflammatory markers, suggesting it could be a safe, natural alternative to conventional antifungal drugs.

In vitro and in vivo inhibitory effects and transcriptional reactions of graphene oxide on Verticillium dahliae

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Scientists discovered that graphene oxide, a nanomaterial, can effectively kill or inhibit the growth of Verticillium dahliae, a harmful fungus that causes wilt disease in cotton and other crops. The graphene oxide works by damaging the fungus’s cell membranes and disrupting its ability to grow and spread. When applied to cotton plants infected with this fungus, graphene oxide treatment reduced disease symptoms and prevented the fungus from multiplying. This research suggests graphene oxide could become a valuable alternative to chemical fungicides for controlling this destructive plant disease.

Fungal infection monitoring on corneal epithelium ex vivo model and its collection over polyethersulfone membrane for detecting Candida albicans and Aspergillus fumigatus

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This research develops a new, faster way to diagnose fungal eye infections caused by Candida or Aspergillus fungi. Instead of waiting days for traditional culture tests, doctors can now use specially designed membranes to collect fungal material from the eye surface and identify the infection within hours using a simple fluorescent staining technique. This faster diagnosis allows doctors to choose the most effective treatment immediately, potentially improving vision outcomes for patients with fungal eye infections.

Roles of the Sec2p Gene in the Growth and Pathogenicity Regulation of Aspergillus fumigatus

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Researchers studied a specific gene called Sec2p in a dangerous fungus that causes serious lung infections in people with weak immune systems. By removing this gene, they found the fungus grew much slower, was less deadly to mice, and the infected animals survived longer. This discovery could lead to new treatments for fungal infections by targeting the Sec2p gene.

Prevalence of Candida and Other Yeasts in Vulvovaginal Infections during Pregnancy: A 10-Year Serbian Survey

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This study examined yeast infections in pregnant Serbian women over 10 years, finding that nearly half had positive tests. While Candida albicans was most common, many other yeast species were also identified, some of which are resistant to common antifungal medications. Using advanced laboratory techniques (MALDI-TOF MS), researchers found more accurate identification was possible, which is important since different yeasts require different treatments, especially during pregnancy when some medications can harm the baby.

Essential Oils as an Antifungal Alternative to Control Several Species of Fungi Isolated from Musa paradisiaca: Part III

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Researchers tested six essential oils from common culinary herbs to control fungal diseases that damage bananas after harvest. Thyme, cinnamon, and oregano oils were most effective at preventing fungal growth at concentrations between 600-1000 parts per million. These natural oils could replace synthetic fungicides in banana storage facilities, providing a safer, more environmentally friendly approach to preserving fruit quality.

Wildlife Dermatophytoses in Central Italy (Umbria and Marche Regions): A Fifteen-Year Investigation (2010–2024)

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Researchers in central Italy studied fungal skin infections in wild animals over 15 years to understand disease patterns and public health risks. They found that about 11% of wild animals tested positive for dermatophytes (skin fungi), with some species dangerous to humans. The most common fungi found were Paraphyton mirabile and Trichophyton mentagrophytes, which can spread to people through contact with infected animals. The study highlights the importance of monitoring wildlife health and using protective equipment when handling wild animals.

Past, present and future of antifungals: Advancements in mechanisms of action and resistance

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Fungal infections are a growing global health threat, especially for people with weakened immune systems, causing millions of deaths annually. Currently available antifungal drugs are limited and increasingly face resistance, making them less effective over time. This special collection of research papers explores new approaches to treating fungal infections, including novel drugs, combination therapies, and alternative treatments to overcome resistance. Scientists and doctors hope these advances will help save more lives by providing better options for treating serious fungal diseases.

Influenza-related invasive pulmonary aspergillosis in an infectious disease ward at a pulmonary referral center in Iran

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This study examined patients hospitalized with influenza who developed a serious fungal infection caused by Aspergillus fungus. Among 109 influenza patients, about 9% developed this fungal complication which significantly increased their risk of death and required longer hospital stays. Patients with existing lung diseases were at higher risk, and those with the fungal infection also had more bacterial superinfections. The findings highlight the importance of recognizing and treating this serious fungal complication in hospitalized influenza patients.

First reported Canadian case of Trichophyton mentagrophytes genotype VII infection among men who have sex with men (MSM)

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A Canadian man contracted a rare fungal skin infection caused by Trichophyton mentagrophytes genotype VII during a trip to Mexico, likely through sexual contact. The infection presented as deep, painful lesions in the genital area that didn’t respond to typical treatments and required 10 weeks of oral and topical antifungal medication to cure. This is the first confirmed case in Canada and highlights the importance of doctors being aware of sexually transmitted fungal infections, especially in patients with unusual rashes that don’t improve with standard treatments.

Research Keyword: antifungal therapy