antifungal susceptibility – Page 7

Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

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Doctors in Thailand have identified a new drug-resistant fungal infection caused by Trichophyton indotineae, a fungus that doesn’t respond to common antifungal medication terbinafine. Five patients were diagnosed with this resistant skin infection that caused rashes on various body parts and failed to improve with standard treatments. The research shows that a simple urease test can help doctors quickly identify this resistant fungus, and a different drug called itraconazole appears to work better for treatment. This is the first time this resistant fungus has been confirmed in Thailand, suggesting it is spreading globally.

Aspergillus terreus sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism

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When Aspergillus terreus fungi are grown in laboratory conditions for extended periods, they sometimes undergo changes that make them look different and behave differently. Scientists found that these changed strains become more susceptible to amphotericin B, a common antifungal drug. By studying the genes and proteins in both the original and changed strains, researchers discovered that special proteins called P-type ATPases appear to be responsible for the fungus’s natural resistance to this drug, offering new targets for developing better antifungal treatments.

Candida glabrata meningitis in a patient with newly diagnosed acquired immunodeficiency syndrome from Sikkim, India

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A middle-aged woman in India was admitted with severe headaches and was found to have a rare fungal infection of the brain (meningitis) caused by Candida glabrata, a type of yeast. She had recently been diagnosed with AIDS and had very low immune cell counts. Although doctors tried multiple antifungal medications, the yeast showed resistance to these drugs and the patient’s condition worsened, ultimately leading to her death. This case highlights how dangerous fungal infections can be in people with severely weakened immune systems.

Spectrum of Fungal Infections in Continuous Ambulatory Peritoneal Dialysis: A 20-Year Retrospective Study From a Tertiary Care Center

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This study examined fungal infections in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) over 20 years at a major Indian hospital. Researchers identified various fungal species causing peritonitis, with Candida species being most common, but discovered increasingly rare fungi involved in these infections. The study found that proper identification of the specific fungus and testing for drug resistance is crucial for effective treatment, typically involving catheter removal and targeted antifungal medications.

Black mold in the bag room: First case of Arthrocladium tropicale peritonitis in a peritoneal dialysis patient

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An 82-year-old dialysis patient developed an unusual infection caused by a black mold called Arthrocladium tropicale, which had never been documented in humans before. The infection was traced to poor storage conditions and ant infestations near the patient’s dialysis supplies in Thailand during rainy season. Doctors identified the rare fungus using molecular genetic testing and treated it successfully with antifungal medication combined with removal of the dialysis catheter. This case highlights the importance of keeping dialysis equipment in clean, dry environments and preventing pest access to prevent serious infections.

A case report of childhood onychomycosis caused by the rare yeast Kodamaea ohmeri

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A 5-year-old girl in Vietnam developed a nail infection caused by a rare yeast called Kodamaea ohmeri, which typically affects adults with diabetes or weak immune systems. The infection, appearing as white discoloration on the nails, was successfully treated with a topical antifungal cream applied three times daily for one month. This is the first reported case of this rare yeast causing nail infection in a child in Vietnam, and it demonstrates that topical treatment can be effective for fungal nail infections in children whose nails are thinner than adults.

Diagnostic Capacity for Fungal Infections in Tertiary Hospitals in Nigeria and Ghana – An Onsite Baseline Audit of 9 Sites

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Researchers audited nine hospital laboratories in Nigeria and Ghana to assess their ability to diagnose fungal infections. They found that most laboratories lack basic equipment like microscopes and trained staff for fungal testing. The study revealed critical gaps in infrastructure and resources needed to identify serious fungal diseases, highlighting the need for investment in laboratory capacity building in African healthcare systems.

Rasamsonia argillacea brain abscess in a lung transplant recipient: an unexpected infection by an unusual fungal pathogen

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A 65-year-old woman who received a lung transplant developed a rare and serious brain infection caused by an unusual fungus called Rasamsonia argillacea. The infection was difficult to diagnose because it looks similar to more common molds under the microscope. During the investigation of this unexpected infection, doctors discovered that the patient had a rare genetic disorder affecting her immune system that had never been diagnosed. This case highlights how unusual infections can reveal hidden immune system problems.

Targeted long-read sequencing analysis and antifungal susceptibility profiles of Sporothrix schenckii isolates from Thailand

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This research examined a fungal infection called sporotrichosis found in Thailand, particularly in cats and humans. Scientists used advanced DNA sequencing technology to accurately identify which species of the fungus caused the infections and understand how they are related to each other. They also tested how well common antifungal medications work against these fungi, finding that some strains have become resistant to itraconazole, the main drug used to treat sporotrichosis.

Unveiling the distribution and research patterns of Aspergillus spp. in Saudi Arabia: a systematic and bibliometric analysis

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This study analyzed over 50 years of research on Aspergillus fungi in Saudi Arabia by examining 520 scientific papers. Researchers found that five main Aspergillus species have been the focus of study, with A. niger being the most researched. The study shows that research has grown significantly since 2010, with Saudi universities leading the efforts, particularly King Saud University. The research is shifting from focusing mainly on medical problems to include agriculture, environment, and industrial applications.

Research Keyword: antifungal susceptibility