antifungal susceptibility – Page 6

Two Cases of Curvularia geniculata Keratitis Successfully Treated with Natamycin-Based Therapy

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Two patients with eye infections caused by a rare fungal species called Curvularia geniculata were successfully treated with antifungal medication. The infections occurred after plant material entered their eyes during daily activities. Doctors identified the exact fungal species through genetic testing and used an antifungal drug called natamycin, alone or combined with another antifungal, to treat the infections. Both patients recovered fully with excellent vision restoration.

RttA, a Zn2-Cys6 transcription factor in Aspergillus fumigatus, contributes to azole resistance

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Researchers discovered that a protein called RttA helps a common fungus called Aspergillus fumigatus resist azole medicines, which are used to treat serious fungal infections. By studying how this protein works and which genes it controls, scientists found that RttA could be a new target for developing better antifungal treatments. The findings are important because azole-resistant fungal infections are becoming more common worldwide and harder to treat.

Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

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Researchers in Thailand have identified the first cases of a new resistant fungal skin infection caused by Trichophyton indotineae. This fungus is resistant to a commonly used antifungal drug called terbinafine and causes persistent skin rashes on various body parts. The study describes five patients whose infections were finally identified through genetic testing and who responded well to alternative antifungal treatment with itraconazole. This discovery suggests the fungus is now spreading in Thailand and doctors should watch for it.

Dermatophytosis in a Chilean fox: first case of Nannizzia gypsea in Lycalopex griseus and the need for a one health approach

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Researchers reported the first case of a fungal skin infection caused by Nannizzia gypsea in a wild South American grey fox found near Santiago, Chile. The fox developed crusted and scaly lesions on its tail, which were successfully treated with topical antifungal cream. This discovery highlights how increasing contact between domestic pets, wild animals, and humans due to urbanization can spread fungal infections, emphasizing the need for integrated health approaches that consider human, animal, and environmental health together.

A case of flexor tenosynovitis caused by Cyberlindnera rhodanensis – First reported human infection

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A patient developed a fungal wrist infection caused by a yeast never before seen in humans, called Cyberlindnera rhodanensis. The infection required six surgeries and five months of antifungal medications to treat. This case shows that new fungal pathogens can cause serious infections even in healthy people, and highlights the importance of proper identification of organisms in medical cultures.

FTIR Characterization and Bioactivity Assessment of Cinnamomum camphora Essential Oil: Antioxidant, Anti-Enzymatic, and Antifungal Properties Against Phytopathogens

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Camphor tree essential oil has been studied for its ability to fight fungal diseases that harm crops and its potential health benefits. The research found that this natural oil completely stops the growth of several harmful fungi at high concentrations, making it a promising eco-friendly alternative to synthetic pesticides. The oil also showed antioxidant properties and may help regulate blood sugar levels, suggesting uses in both agriculture and medicine.

Aspergillus fumigatus ctf1 – a novel zinc finger transcription factor involved in azole resistance

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A. fumigatus is a dangerous fungal infection that kills many immunocompromised patients and increasingly resists common antifungal drugs. Researchers identified a key protein called ctf1 that helps the fungus resist the drug voriconazole by pumping it out of fungal cells and altering the fungal cell membrane. Understanding how ctf1 works could lead to new treatments for these difficult-to-treat infections.

Clinical characterization of immunocompetent patients with Scedosporium detected in respiratory samples: A case series

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This study examined eight elderly patients without compromised immune systems who had the fungus Scedosporium detected in their lungs. All patients had a condition called bronchiectasis, and most had previously suffered from MAC disease. The researchers found that in most cases, the fungus was just colonizing the lungs without causing active infection. The challenge for doctors is determining whether Scedosporium is simply living in the lungs or actively causing disease.

Epidemiology of Candidemia, Candiduria and Emerging Candidozyma (Candida) auris Across Gulf Cooperative Council Countries and Yemen in the Arabian Peninsula

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This comprehensive review examines fungal bloodstream and urinary tract infections caused by Candida species across Middle Eastern countries. The study shows that while Candida albicans remains common, dangerous antibiotic-resistant strains like Candidozyma auris are increasingly appearing in hospitals. The research highlights that better diagnostic tools and infection prevention practices are urgently needed in the region to protect patients and reduce deaths from these serious infections.

The refractory nailbed ulceration caused by Candida parapsilosis after nail extraction

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An 82-year-old woman developed a stubborn wound on her toenail bed after having her nail surgically removed to treat an infection. When the wound did not heal for six months, doctors discovered it was caused by a fungus called Candida parapsilosis, which is normally found on skin but can cause infections when given the opportunity through wounds. After identifying the fungus, doctors treated her with an antifungal medication called fluconazole for three months, and her wound completely healed. This case shows the importance of testing chronic nail infections for their specific cause before performing surgery.

Research Keyword: antifungal susceptibility