antifungal susceptibility – Page 11

Exploring the Antifungal Potential of Lawsone-Loaded Mesoporous Silica Nanoparticles Against Candida albicans and Candida glabrata: Growth Inhibition and Biofilm Disruption

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Researchers developed a new antifungal treatment by loading lawsone (a compound from henna plants) into tiny particles called mesoporous silica nanoparticles. When tested against common fungal infections caused by Candida bacteria, this nano-formulation was more effective than lawsone alone at killing the fungi and breaking down protective biofilm structures. The treatment showed no harm to normal human cells, suggesting it could be a promising natural alternative to treat stubborn fungal infections that resist current antifungal drugs.

Candidemia due to Candida lambica in a neutropenic oncology patient: A rare case report

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A 56-year-old cancer patient developed a rare blood infection caused by an unusual yeast called Candida lambica while receiving chemotherapy. Despite taking antifungal medication for prevention, the patient developed a serious fever and low white blood cell count. Doctors identified the infection through genetic testing and treated it with a different antifungal drug called voriconazole, which successfully cleared the infection.

Evaluation of the Cytotoxicity and Antifungal Efficacy of Crocus sativus (saffron) Petals on Clinical Isolates of Candida albicans

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Researchers tested saffron petals to see if they could fight Candida albicans yeast infections. While saffron extract showed some antifungal activity, it was less powerful than the standard drug fluconazole. However, saffron was very safe and non-toxic to human cells, making it a promising natural alternative therapy worth exploring further.

Neonatal Invasive Candidiasis: Current Concepts

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Serious fungal infections (candidiasis) in newborns have become increasingly difficult to treat, especially in developing countries. The types of fungi causing these infections have changed dramatically, with many now resisting the standard fluconazole treatment. Modern medical care, like proper handwashing, environmental cleaning, and careful line care, is actually more effective at preventing these infections than giving preventive antifungal drugs. Healthcare providers need better tools for quickly identifying which fungal species is causing infection and which drugs will work against it.

Brown locusts, Locustana pardalina, host fluconazole-resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains

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Researchers discovered that brown locusts in South Africa can carry a dangerous drug-resistant fungus called Candida auris in their digestive systems. This fungus, which causes serious infections in hospitals and is resistant to the antifungal drug fluconazole, may use locusts as a way to spread to humans or other environments. The study suggests that insects could play an important role in how dangerous fungi emerge and spread globally, particularly in warm climates where locusts thrive.

Utility of MALDI-ToF MS for Recognition and Antifungal Susceptibility of Nannizzia, an Underestimated Group of Dermatophytes

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Nannizzia species are soil-dwelling fungi that increasingly cause stubborn skin, nail, and hair infections in humans and animals. This study tested two laboratory methods for identifying these fungi and measured their sensitivity to eight antifungal drugs. The faster liquid-based method was slightly more accurate (67%) than the traditional culture method (62%), though neither method could identify six very rare species. Terbinafine emerged as the most effective antifungal treatment in laboratory tests.

Evaluation of Antifungal Activity Against Candida albicans Isolates From HIV-Positive Patients with Oral Candidiasis in a Major Referral Hospital, West Java, Indonesia

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This study examined fungal infections in HIV-positive patients’ mouths at an Indonesian hospital. Researchers identified which Candida species caused the infections and tested how well common antifungal medications worked against them. They found that while a specific antifungal drug (fluconazole) was effective in most cases, some infections showed resistance, suggesting the need for careful monitoring and personalized treatment approaches.

Clinical characterization of immunocompetent patients with Scedosporium detected in respiratory samples: A case series

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This study examined eight elderly patients without compromised immune systems who had Scedosporium fungus detected in their lungs. All patients had a condition called bronchiectasis and most had previously suffered from a lung infection called MAC disease. The researchers found that in most cases, the fungus was simply living in the lungs without causing active infection, though distinguishing between these two situations proved difficult. Only one patient was diagnosed with an active Scedosporium infection and required antifungal treatment with a drug called voriconazole.

The Brief Case: Cutaneous ulceration associated with acalabrutinib treatment

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A 72-year-old patient being treated with acalabrutinib for blood cancer developed a slowly growing skin ulcer on the thigh. Testing identified a fungal infection caused by Alternaria alternata, a mold found in soil and air. The patient was successfully treated with an antifungal medication called posaconazole, with the ulcer healing over one month. This case highlights that doctors should check for fungal infections in chronic skin wounds of patients taking BTK inhibitor medications.

Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review

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A 50-year-old woman with advanced lung cancer developed a rare fungal eye infection caused by Cryptococcus neoformans, resulting in blurred vision. Doctors diagnosed this through eye surgery and fluid analysis, then treated her with strong antifungal medications both injected into the eye and given systemically. After 10 months of treatment, her vision significantly improved, showing that early detection and aggressive antifungal therapy are critical for preventing blindness from this rare infection.

Research Keyword: antifungal susceptibility