antifungal resistance – Page 2

Fusarium Corneal Abscess: A Case Report

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A 20-year-old healthy patient developed a serious fungal eye infection caused by Fusarium, a common soil fungus, despite having no typical risk factors like eye trauma or contact lens wear. The infection created an abscess (collection of pus) in the cornea and threatened the patient’s vision. Doctors used a combination of antifungal medications and eventually transplanted amniotic membrane tissue to prevent the cornea from rupturing, preserving the patient’s eyesight.

Pathogenic potential of polyextremotolerant fungi in a warming world

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Certain fungi can survive extremely harsh conditions like extreme temperatures and dry environments, and many of these same species can cause infections in humans. As the planet warms due to climate change, these fungi are becoming better adapted to higher temperatures, which makes them more dangerous as human pathogens. Scientists are working to better understand these fungi and develop new treatments and vaccines to protect people from fungal infections.

A case report of disseminated histoplasmosis not responding to primary treatment by itraconazole

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A 28-year-old woman developed a fungal infection called histoplasmosis after having a tooth extracted, with the infection spreading to her lungs and sinuses. She was initially given a common antifungal medication called itraconazole, but her condition continued to worsen despite increasing the dose. When doctors switched her to a stronger medication called liposomal amphotericin B given intravenously, she improved dramatically and recovered fully. This case shows the importance of recognizing when a standard fungal treatment is not working and switching to more aggressive therapy.

Development of reverse transcription loop-mediated isothermal amplification-based assay for rapid and specific detection of human fungal pathogen, Candida auris

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Researchers developed a new rapid test called RT-LAMP to detect Candida auris, a dangerous multidrug-resistant fungus that causes hospital infections. The test works by changing color from pink to yellow when the fungus is present, making it easy to read without special equipment. It is more sensitive and specific than current methods, can be done quickly at a single temperature, and costs much less than existing tests, making it ideal for hospitals and clinics with limited resources.

Advances in Fungal Infection Research: From Novel Diagnostics to Innovative Therapeutics

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Fungal infections are becoming increasingly serious, especially for people with weakened immune systems, and some fungi are developing resistance to current medications. Researchers are developing faster diagnostic tests using molecular techniques and exploring new treatment approaches including repurposing existing drugs and developing vaccines. Monitoring and prevention programs in hospitals are essential to control the spread of these infections and improve patient outcomes.

Candida vulturna, the Next Fungal Menace? A Narrative Review

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Candida vulturna is a newly discovered yeast that causes serious blood infections, particularly in vulnerable patients like premature infants and those with cancer. Though still rare, cases are increasingly appearing in tropical regions with documented hospital outbreaks. While the infection has a better survival rate than related species, it resists several common antifungal drugs, making treatment challenging and requiring careful use of remaining effective medications.

Recognizing the Importance of Public Health Mycology

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Fungal infections are becoming a major global health problem, causing millions of cases and deaths each year, especially in people with weakened immune systems. Different types of fungal infections like aspergillosis and candidiasis are becoming harder to treat because fungi are developing resistance to antifungal medications. The editorial emphasizes that better diagnosis, treatment access, and disease tracking are needed worldwide to combat this growing threat.

The dimorphic fungus Talaromyces marneffei: An opportunistic killer in Southeast Asia

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Talaromyces marneffei is a dangerous fungus found in Southeast Asian soils that causes serious lung infections when people breathe in its spores. The fungus has a clever trick: it transforms into different forms depending on temperature and hides inside immune cells by tricking them. People with weak immune systems, particularly those with advanced HIV/AIDS or certain genetic conditions, are most vulnerable to severe disease.

Epidemiology and outcomes of Candida-associated osteoarticular infections: A multicentre retrospective study from Turkey

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This study examined 73 patients in Turkey who developed bone and joint infections caused by Candida fungi over ten years. The researchers found that diabetes was very common among patients and made recovery harder, while surgery to clean out infected tissue significantly improved outcomes. Importantly, they discovered resistance to common antifungal medications was higher in certain Candida species compared to others.

Refractory fungal infection: Three case reports highlighting good practice

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This case series examines three patients with serious fungal infections that did not respond well to standard antifungal treatments. The cases demonstrate how fungi can develop resistance to common antifungal drugs like azoles, making infections harder to treat. The authors emphasize that accurate identification of the fungus, testing its sensitivity to drugs, monitoring drug levels in the blood, and careful use of antifungal medications are essential for successfully treating these difficult infections.

Research Keyword: antifungal resistance