Research Keyword: antifungal mechanisms

Graphene nanomaterials: A new frontier in preventing respiratory fungal infections

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Fungal lung infections are a serious problem, especially for people with weak immune systems. Researchers are exploring graphene nanomaterials as a new treatment approach that can deliver antifungal drugs directly to infected areas in the lungs. These tiny particles work by creating toxic stress inside fungal cells and breaking down their protective biofilms, while using smaller drug doses and causing fewer side effects than traditional treatments.

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Combination of Q-switched 1,064 and 532 nm Nd: YAG laser in the treatment of toenail onychomycosis: a pilot study

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This study tested a laser treatment using two different wavelengths (1,064 and 532 nanometers) to treat toenail fungal infections. Fifteen patients with toenail fungus received eight weekly laser sessions. The treatment was safe and worked best for mild cases, curing 100% of them, but was less effective for severe infections. Although patients experienced some pain during treatment, the overall results suggest laser therapy could be a useful option for treating mild fungal toenail infections without the side effects of oral medications.

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Antimicrobial effects and mechanisms of hydrogen sulphide against nail pathogens

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Researchers discovered that hydrogen sulphide (H2S), a small gas molecule, can effectively kill the fungi and bacteria that cause painful nail infections. Unlike current treatments that struggle to penetrate into the nail, hydrogen sulphide easily diffuses through the nail plate. The study found that H2S works by damaging the fungi’s respiratory system and creating harmful reactive oxygen species, while also modifying proteins in a way that disrupts their normal function. This innovative approach could offer patients a new topical treatment option for nail infections that have been difficult to treat with existing medications.

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Evaluating the Role of Nutrient Competition in Debaryomyces hansenii Biocontrol Activity Against Spoilage Molds in the Meat Industry

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This research examined how a beneficial yeast called Debaryomyces hansenii prevents dangerous molds from growing on cured meat products. Scientists compared different strains of this yeast and tested whether it works by competing with molds for nutrients. While the yeast successfully stopped mold growth and spore production, nutrient competition wasn’t the main reason—other mechanisms like direct interactions between the microorganisms were more important. This suggests D. hansenii could be a natural alternative to chemical preservatives in the meat industry.

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Biocontrol Potential of a Mango-Derived Weissella paramesenteroides and Its Application in Managing Strawberry Postharvest Disease

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Researchers discovered that a beneficial bacteria called Weissella paramesenteroides, naturally found on mango surfaces, can protect strawberries from fungal spoilage. This bacteria works by releasing special aromatic compounds (VOCs) into the air that kill disease-causing fungi without direct contact. When used in strawberry storage boxes, this biocontrol method reduced fruit disease from 70% to 35%, offering a safer, natural alternative to synthetic fungicides.

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Unveiling molecular mechanisms of strobilurin resistance in the cacao pathogen Moniliophthora perniciosa

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This research reveals how a fungus that causes disease in cacao plants survives treatment with strobilurin fungicides, which are commonly used in agriculture. Scientists discovered that the fungus adapts by reorganizing its metabolism to compensate for the drug’s effects, activating detoxification systems, and in some cases, developing genetic mutations that enhance resistance. Understanding these survival mechanisms could help develop better strategies to control this economically important crop disease.

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Graphene nanomaterials: A new frontier in preventing respiratory fungal infections

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Scientists are exploring nano-graphene oxide, a microscopic material made from graphene, as a new treatment for serious lung fungal infections. These tiny particles can kill fungal cells through multiple mechanisms and deliver antifungal drugs directly to infection sites while reducing harmful side effects. Researchers found that graphene oxide can be combined with existing antifungal medications to make them work better and even help overcome drug-resistant fungal infections.

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