Research Keyword: antibiotic resistance

Natural Antimicrobial Compounds as Promising Preservatives: A Look at an Old Problem from New Perspectives

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This review examines natural alternatives to synthetic food preservatives, which are increasingly recognized as potentially harmful. Natural antimicrobial compounds from plants, fungi, and other sources can effectively prevent food spoilage and bacterial contamination. New technologies using light and ultrasound can enhance these natural compounds’ effectiveness. While promising, these natural preservatives need more research and regulatory approval before widespread industrial use.

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Screening of Basidiomycete Strains Capable of Synthesizing Antibacterial and Antifungal Metabolites

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Researchers tested 18 types of medicinal mushrooms to see if they could produce natural antibiotics. Most of them (16 out of 18) showed antimicrobial properties, with some being particularly effective against dangerous bacteria and fungi. The most promising mushroom strain (Hericium corraloides 4) showed strong activity against multiple disease-causing organisms. This research suggests that mushrooms could be valuable sources for developing new antibiotics to fight drug-resistant infections.

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Editorial: Innovation in tackling the global challenge of eradicating antibiotic-resistant microorganisms

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Antibiotic resistance is a serious global health problem causing millions of deaths annually. Scientists are developing new approaches to fight resistant bacteria, including using bacteriophages (viruses that attack bacteria), improving detection methods, and testing plant-based compounds. This editorial discusses 15 research papers showing various innovative strategies, emphasizing that we need multiple tools working together rather than relying on any single solution to solve this complex problem.

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Screening of Basidiomycete Strains Capable of Synthesizing Antibacterial and Antifungal Metabolites

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Researchers tested 18 different types of wood-decay fungi (basidiomycetes) to see if they could produce natural antibiotics and antifungal compounds. They found that 16 of the 18 strains successfully produced antimicrobial substances. Five strains were particularly promising, showing strong activity against dangerous bacteria including antibiotic-resistant strains. The study identified specific chemical compounds from these fungi that could potentially be developed into new medicines.

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Clinical insights into mixed Candida and bacterial bloodstream infections: a retrospective cohort study

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This study found that when both Candida fungus and bacteria are present together in a patient’s bloodstream, the outcome is much more serious than when only Candida is present. Among patients with these mixed infections, over 60% died within 30 days compared to about 52% for those with only Candida. The research shows that giving the right antibiotics early and following proper treatment guidelines can significantly improve survival chances in these severe, life-threatening infections.

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Microbe Profile: Streptomyces formicae KY5: an ANT-ibiotic factory

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Scientists discovered a special bacterium called Streptomyces formicae living in ant nests in Africa that produces powerful antibiotics effective against dangerous drug-resistant bacteria and fungi. This bacterium has the genetic potential to make at least 45 different antimicrobial compounds, though most are not currently being produced under standard laboratory conditions. Using advanced gene-editing techniques like CRISPR, researchers are working to activate these hidden pathways to discover new medicines. This research demonstrates how exploring bacteria in nature can lead to finding new antibiotics to treat serious infections.

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