antibiotic resistance – Page 2

Fungal Drug Discovery for Chronic Disease: History, New Discoveries and New Approaches

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This article examines how fungi have provided humanity with some of the most important medicines ever created, including penicillin, drugs that prevent organ rejection, and cholesterol-lowering statins. Many of these fungal compounds work as medicines because they target processes that are similar in both fungi and humans, helping them survive competition with other fungi while coincidentally treating human diseases. New researchers are now using modern genetic tools to discover additional fungal medicines, with several promising candidates currently being tested in clinical trials for cancer, depression, and other chronic diseases.

Isolation of Actinobacteria from Date Palm Rhizosphere with Enzymatic, Antimicrobial, Antioxidant, and Protein Denaturation Inhibitory Activities

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Researchers isolated bacteria called actinobacteria from soil around date palm roots in Algeria’s Sahara Desert. One promising strain, Streptomyces sp. SGI16, was found to produce multiple enzymes and compounds with strong antimicrobial and antioxidant properties. These findings suggest desert microorganisms could be valuable sources for developing new medicines and agricultural products.

Evaluation of resistance patterns and bioremoval efficiency of hydrocarbons and heavy metals by the mycobiome of petroleum refining wastewater in Jazan with assessment of molecular typing and cytotoxicity of Scedosporium apiospermum JAZ-20

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Scientists isolated fungi from oil refinery wastewater in Saudi Arabia and discovered that a fungus called Scedosporium apiospermum JAZ-20 is exceptionally good at removing harmful metals and oil pollutants from contaminated water. This fungus was also tested on human cancer cells and showed promise as a potential anti-cancer agent while being relatively safe. The research suggests this fungus could be used as an eco-friendly solution to clean up polluted industrial wastewater.

Antibiotic Resistance Genes in Agricultural Soils: A Comprehensive Review of the Hidden Crisis and Exploring Control Strategies

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Antibiotics used in farming and medicine are creating resistant bacteria that accumulate in soil, threatening food safety and human health through the food chain. This review explains how these resistant genes spread through soil microorganisms and presents practical solutions including special soil treatments, chemical processes, and beneficial microorganisms to reduce the problem. The authors emphasize the need for stricter regulations on antibiotic use in agriculture and better management of farm manure to protect both soil health and public health.

Biomimetic Nanotechnology Vol. 3

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Scientists are developing new technologies inspired by nature at extremely small scales to solve real-world problems. This collection showcases five innovative studies using mushrooms and plants to create nanoparticles, developing new treatments for heart disease, and creating smart materials that can detect harmful chemicals. These nature-inspired approaches are often safer, more sustainable, and more effective than traditional methods.

Synbiotic microencapsulation of Lactiplantibacillus plantarum-lentinan for enhanced growth in broilers

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Researchers developed a special protective coating for beneficial bacteria called L. plantarum mixed with lentinan from mushrooms. This mixture helps chickens grow better and stay healthier by improving their digestion and fighting harmful bacteria. When the coated bacteria reach the chicken’s intestines, they release their beneficial properties, improving growth rate and immune function without using antibiotics.

Occurrence and Distribution of Antibiotics and Antibiotic Resistance Genes in the Water and Sediments of Reservoir-Based Drinking Water Sources in Henan, China

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This study examined three drinking water reservoirs in China to understand how antibiotic-resistant bacteria spread through water and sediment. Researchers found that mobile genetic elements (like integrons) play a bigger role than antibiotics themselves in spreading resistance genes among bacteria. One reservoir, Jian’gang, naturally removed most resistance genes as water flowed through, suggesting its natural purification processes are quite effective. Understanding how these factors work together helps protect drinking water supplies from antibiotic-resistant bacteria.

Endophytic fungi isolated from Vietnamese nut grass (Cyperus rotundus L. Cyperaceae) – A promising solution to mitigate the prime phenomenon of antibiotic resistance

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Scientists discovered seven types of fungi living inside nut grass plants that can fight dangerous bacteria, including those resistant to current antibiotics. These fungi showed strong ability to kill drug-resistant staph bacteria and other serious pathogens. The findings suggest that these naturally-occurring fungi could be developed into new antibiotics to treat infections that currently have limited treatment options.

Draft Genome Sequence of the Coprinoid Mushroom Coprinopsis strossmayeri

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Scientists sequenced the complete genetic blueprint of Coprinopsis strossmayeri, a mushroom that lives in dung. By analyzing its genome, they discovered the mushroom produces multiple types of chemical compounds with antimicrobial properties that could be useful for developing new medicines. The research highlights how fungi living in competitive environments like dung have evolved to produce substances that could benefit human health through pharmaceutical applications.

mGem: How many fungal secondary metabolites are produced by filamentous fungi? Conservatively, at least 1.4 million

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Scientists have discovered about 30,000 fungal compounds with useful properties, from life-saving antibiotics like penicillin to cholesterol-lowering drugs. However, new research suggests that fungi actually produce somewhere between 1.4 million and 4.3 million different chemical compounds, meaning we’ve only discovered about 1-2% of what’s out there. By studying the genomes of fungi, researchers estimate that for every fungal medicine we know about, there could be 50-100 more waiting to be discovered, representing an enormous opportunity for developing new drugs and therapies.

Research Keyword: antibiotic resistance