Research Keyword: anti-tumor

Chromosome-Scale Genome and Transcriptomic Analyses Reveal Differential Regulation of Terpenoid Secondary Metabolites in Hericium coralloides

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Researchers sequenced the complete genome of Hericium coralloides, an edible medicinal mushroom, at the chromosome level for the first time. They identified genes responsible for producing terpenoids, which are beneficial compounds with antioxidant, anti-inflammatory, and anti-tumor properties. The study found that these beneficial compounds are produced in higher amounts in the mushroom’s mycelium (root-like structure) compared to fruiting bodies, which could help optimize mushroom cultivation for medicinal use.

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Insights into the Mycosphere Fungal Community and Its Association with Nucleoside Accumulation in Ophiocordyceps sinensis

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Chinese cordyceps (Ophiocordyceps sinensis) is a precious medicinal fungus found on the Tibetan Plateau that has anti-inflammatory and anti-tumor properties. Researchers studied the fungi living in soil around wild cordyceps and found that the types and amounts of these soil fungi are connected to how much medicinal compounds accumulate in the cordyceps. Samples from certain regions like Yushu had more diverse soil fungi and higher levels of beneficial compounds called nucleosides. This suggests that managing soil fungi could help improve the quality of cordyceps grown in cultivation.

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Study on Optimization of Liquid Fermentation Medium and Antitumor Activity of the Mycelium on Phyllopora lonicerae

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Scientists optimized how to grow Phylloporia lonicerae fungus in the lab, increasing its production by 142% while cutting growth time by two-thirds. They discovered that certain compounds extracted from this fungus, particularly from a petroleum ether extract, can kill cancer cells and trigger apoptosis. The petroleum ether extract was more effective than the standard cancer drug 5-fluorouracil, especially against esophageal cancer cells, suggesting this fungus could be developed into a natural anti-cancer treatment.

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Study on Optimization of Liquid Fermentation Medium and Antitumor Activity of the Mycelium on Phyllopora lonicerae

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Researchers improved the production of a medicinal fungus called Phylloporia lonicerae that grows on honeysuckle plants. They developed a better growing medium that produced more fungus in less time. They then discovered that components from this fungus can kill cancer cells, particularly lung and esophageal cancer cells, by triggering a natural cell death process called apoptosis. This work suggests the fungus could be developed into an anti-cancer functional food.

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