anti-inflammatory – Page 4

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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Scientists studied a medicinal mushroom called Taiwanofungus gaoligongensis to understand how different growing methods affect the production of beneficial compounds. They found that growing the mushroom in special bags with certain wood substrates produced far more of the valuable compounds (up to 12-fold more) compared to growing it on rice medium. By examining which genes were active in different growing conditions, they discovered how the mushroom’s cells control the production of these medicinal compounds, which could help farmers grow more potent medicinal mushrooms.

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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This study examined how different growing methods affect the medicinal compounds found in Taiwanofungus gaoligongensis, a rare Chinese medicinal fungus. Researchers discovered that growing this fungus on wood substrates from specific trees significantly increased production of beneficial compounds like antcins and antrodin C, which have anti-cancer and anti-inflammatory properties. By analyzing gene expression patterns, they identified key genes and regulatory mechanisms that control the production of these medicinal compounds, suggesting ways to improve cultivation methods for better medicinal value.

Insights into metabolic and pharmacological profiling of Aspergillus ficuum through bioinformatics and experimental techniques

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Researchers studied a fungus called Aspergillus ficuum and found it contains compounds with potential medicinal benefits. The fungal extract showed strong antibacterial activity against disease-causing bacteria and reduced inflammation in mice. Additionally, the extract had antioxidant properties that help fight harmful free radicals, with no toxic effects observed, making it a promising candidate for developing new medications.

Haplotype-Phased Chromosome-Level Genome Assembly of Floccularia luteovirens Provides Insights into Its Taxonomy, Adaptive Evolution, and Biosynthetic Potential

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Scientists have created the most detailed genetic map of the yellow mushroom (Floccularia luteovirens), a highly valued medicinal and edible fungus from the Tibetan Plateau. Using advanced sequencing technology, they mapped its 13 chromosomes and identified 15 pathways that the mushroom uses to make potentially useful healing compounds. The research also solved a long-standing mystery about the mushroom’s family tree, proving it is not actually related to Armillaria mushrooms as previously thought. This genetic blueprint opens new possibilities for developing medicines from this special fungus.

New bioactive secondary metabolites from fungi: 2024

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Scientists discovered 907 new compounds from fungi in 2024, with most being terpenoids and polyketides that show promise as medicines. These fungal compounds demonstrate strong activity against bacteria, fungi, and inflammation, with some showing potential against cancer and diabetes. The research uses advanced techniques like genome mining and metabolomics to find these compounds more efficiently. This accelerating discovery rate suggests fungi could be a major source for developing new drugs to treat various diseases.

Anticancer Activity of Demethylincisterol A3 and Related Incisterol-Type Fungal Products

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This review examines a group of rare fungal compounds called incisterols, with a focus on demethylincisterol A3 (DM-A3), which has shown promise as an anticancer agent. DM-A3 works through multiple mechanisms including blocking cancer cell signaling pathways, inhibiting specific enzymes, and reducing inflammation. The compound has demonstrated effectiveness against various cancer types in laboratory studies and showed tumor-reducing effects in animal models, suggesting potential for future cancer therapy development.

Updated Taxonomy of Chinese Craterellus (Hydnaceae, Cantharellales) with Three New Species Described

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Scientists have discovered and described three new species of trumpet mushrooms (Craterellus) found in China. These mushrooms are valuable because they form helpful relationships with trees and have medicinal properties. By studying both the physical characteristics and DNA of 109 mushroom samples, researchers identified seventeen different Craterellus species in China, greatly expanding our understanding of this important group of edible fungi.

Chemical Composition and In Vitro Biological Activity of the Polar and Non-Polar Fractions Obtained from the Roots of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim

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Siberian ginseng (Eleutherococcus senticosus) roots contain powerful antioxidant compounds that may help with inflammation, blood sugar control, and brain health. Researchers found that certain plant fractions were particularly rich in protective compounds like chlorogenic acid and caffeic acid. However, the study also discovered a concerning finding: these plant compounds protected cancer cells from chemotherapy drugs, suggesting people undergoing cancer treatment should be cautious about using this supplement.

Insights into the Mycosphere Fungal Community and Its Association with Nucleoside Accumulation in Ophiocordyceps sinensis

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Chinese cordyceps (Ophiocordyceps sinensis) is a precious medicinal fungus found on the Tibetan Plateau that has anti-inflammatory and anti-tumor properties. Researchers studied the fungi living in soil around wild cordyceps and found that the types and amounts of these soil fungi are connected to how much medicinal compounds accumulate in the cordyceps. Samples from certain regions like Yushu had more diverse soil fungi and higher levels of beneficial compounds called nucleosides. This suggests that managing soil fungi could help improve the quality of cordyceps grown in cultivation.

Chitosan and Chitooligosaccharide: The Promising Non-Plant-Derived Prebiotics with Multiple Biological Activities

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Chitosan and chitooligosaccharide are natural compounds derived from crustacean shells and fungi that act as prebiotics to improve gut health. These compounds can fight bacteria and viruses, reduce inflammation, protect against oxidative stress, and help maintain healthy weight and blood sugar levels. They represent a promising, biodegradable alternative to synthetic pharmaceuticals with multiple health benefits.

Research Keyword: anti-inflammatory