Research Keyword: anti-inflammatory agents

Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Aegle marmelos Juice

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Researchers tested a fermented bael fruit juice with probiotics as a treatment for ulcerative colitis in mice. The mice treated with this juice showed significant improvement in weight recovery, reduced inflammation markers, and increased antioxidant protection compared to untreated diseased mice. The fermentation process increased the beneficial compounds in the juice. These results suggest that probiotic-fermented bael fruit juice could be a natural and effective treatment option for people with ulcerative colitis.

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Nature’s Own Pharmacy: Mushroom-Based Chemical Scaffolds and Their Therapeutic Implications

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This comprehensive review explores how mushrooms can be used as natural medicines. Various mushroom species contain powerful compounds that can fight cancer, boost immunity, reduce inflammation, and treat infections. The paper details 15 important medicinal mushrooms and their therapeutic uses, showing that mushrooms are indeed a nature’s pharmacy with significant potential for treating many diseases.

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The Effect of Combined Treatment of Psilocybin and Eugenol on Lipopolysaccharide-Induced Brain Inflammation in Mice

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This study tested whether psilocybin (an active compound from magic mushrooms) combined with eugenol (a natural compound from cloves) could reduce brain inflammation in mice. Researchers gave mice a substance that triggers inflammation in the brain and then treated them with these compounds before or after the inflammation started. The combination treatment, especially at a 1:50 ratio of psilocybin to eugenol, significantly reduced multiple inflammatory markers in the brain, suggesting this combination could potentially be helpful for treating brain inflammation-related conditions.

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Towards engineering agaricomycete fungi for terpenoid production

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Mushroom-forming fungi, particularly species like shiitake and oyster mushrooms, naturally produce valuable compounds called terpenoids used in medicines, food, and cosmetics. Scientists are learning to genetically engineer these fungi to produce even larger amounts of these beneficial compounds, potentially making them as important to biotechnology as baker’s yeast and mold have been historically. This could create new sustainable sources for medicinal compounds and industrial chemicals.

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Bioactive Steroids Bearing Oxirane Ring

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This research reviews special types of steroids that contain oxirane rings, which are highly reactive chemical structures found in marine organisms, fungi, and plants. These compounds have shown promise in treating various diseases including cancer, inflammation, and high cholesterol. Scientists used computer software to predict and analyze the biological activities of over 150 different epoxy steroids, categorizing them by the position of their oxirane ring. The findings suggest these natural compounds could be valuable for developing new medicines and understanding how chemicals interact with our bodies.

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Ergostane-type steroids from mushrooms of Pleurotus genus

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Oyster mushrooms and king trumpet mushrooms contain special compounds called ergostane-type steroids that have interesting chemical structures. These compounds can fight inflammation and may help with cancer. Scientists have discovered that some of these compounds have unique rearranged structures that don’t exist in other organisms. These mushroom-derived compounds show promise for developing new medicines.

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Chemical Characterization and In Vitro Antioxidant, Anti-Inflammatory, and Colon Cancer-Preventive Potential of a Polysaccharide Fraction from Macrolepiota procera

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Researchers isolated special sugar compounds called polysaccharides from parasol mushrooms and tested their health benefits. These compounds were found to fight free radicals that damage cells, reduce inflammation in the body, and specifically kill colon cancer cells while leaving healthy cells unharmed. The study suggests that parasol mushrooms could be developed into health supplements or functional foods to help prevent cancer and improve overall health.

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