Research Keyword: anti-cancer

A multilocus phylogeny of Hericium (Hericiaceae, Russulales)

Researchers conducted the first comprehensive genetic study of lion’s mane mushrooms (Hericium species) using advanced DNA sequencing techniques. The study resolved long-standing confusion about different species and their relationships, while also describing a new species from western North America. These mushrooms are prized both as food and for traditional medicinal uses, particularly in Asia, and contain compounds with potential anti-inflammatory, antimicrobial, and neuroprotective properties. Better identification of species will help both commercial cultivators and medical researchers work with the correct organisms.

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From natural laboratory to drug discovery: Chemical structures, bioactivities, and biosynthesis of meroterpenoids from Ganoderma species

This review examines special compounds called meroterpenoids found in Ganoderma mushrooms (commonly known as Reishi). Scientists have identified over 350 of these compounds from 14 different Ganoderma species. These compounds show promise for treating various health conditions including cancer, kidney disease, diabetes, and inflammatory disorders. The researchers also propose how these compounds are made inside the mushroom, which could help scientists produce them more efficiently for medical use.

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Research Progress on Nutritional Components, Functional Active Components, and Pharmacological Properties of Floccularia luteovirens

Floccularia luteovirens is a special mushroom from the Qinghai-Tibet Plateau that has been used in traditional Tibetan medicine for centuries. It is extremely nutritious, containing as much protein as meat and numerous beneficial compounds. Scientific research shows it can help fight disease, boost immunity, and even preserve food naturally, making it promising for development as a health supplement and functional food.

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Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast

Scientists successfully engineered baker’s yeast to produce ganoderic acids, potent anti-cancer compounds from medicinal mushrooms, at much higher levels than found in farmed mushrooms. By identifying key enzymes responsible for converting simpler compounds into active ganoderic acids, researchers created yeast strains that produce these valuable compounds 100-10,000 times more efficiently than traditional mushroom farming. This breakthrough could make these expensive medicinal compounds more accessible and affordable for medical research and potential drug development.

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