Research Keyword: anterior cingulate cortex

Social pain: A systematic review on interventions

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This study reviews different treatments for social pain—the emotional hurt from rejection and social exclusion. Researchers found that regular pain reliever acetaminophen, mindfulness meditation, and the psychedelic compound psilocybin can reduce social pain, while placebo pills also help when people believe they work. Interestingly, combining acetaminophen with forgiveness works better than either alone, suggesting that both physical and emotional pain may use similar brain pathways.

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Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum

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Researchers found that serotonin and psilocybin (the active compound in magic mushrooms) work through the same brain mechanism to suppress certain neural signals in a brain region called the claustrum. This region controls how different parts of the cortex communicate with each other. The study shows that psilocybin directly targets serotonin 5-HT1B receptors to quiet down signals from one brain area to another, which may explain how psychedelics change cortical network activity and alter consciousness.

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Axin2 coupled excessive Wnt-glycolysis signaling mediates social defect in autism spectrum disorders

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Autism spectrum disorder affects social abilities in millions of people, but the underlying causes remain poorly understood. This research discovered that in the brains of people with autism, certain cellular processes that control energy and signaling become overactive, particularly in the region controlling social behavior. The good news is that the researchers found a drug-like compound called XAV939 can restore normal function by blocking the abnormal interaction between two key proteins, potentially offering a new treatment approach.

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