Research Keyword: animal model

Prebiotics and Probiotics Supplementation in Pigs as a Model for Human Gut Health and Disease

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Pigs are excellent models for studying human digestive health because their gut anatomy and function closely resemble humans. This review shows that prebiotics (special food compounds) and probiotics (beneficial bacteria) can improve gut health and strengthen the intestinal barrier in both healthy pigs and those with infections. These findings suggest that similar treatments might help prevent and treat digestive diseases in humans.

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Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Aegle marmelos Juice

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Researchers tested a fermented bael fruit juice with probiotics as a treatment for ulcerative colitis in mice. The mice treated with this juice showed significant improvement in weight recovery, reduced inflammation markers, and increased antioxidant protection compared to untreated diseased mice. The fermentation process increased the beneficial compounds in the juice. These results suggest that probiotic-fermented bael fruit juice could be a natural and effective treatment option for people with ulcerative colitis.

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Psilocybin Does Not Induce Conditioned Place Preference, But Modifies Behavioral Patterns in Sprague-Dawley Rats

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Researchers tested whether psilocybin, a compound found in magic mushrooms, could be addictive by examining reward-seeking behavior in rats. The study found that psilocybin did not create rewarding effects that would typically lead to addiction, and only temporarily changed specific behaviors like head-twitching and grooming while the drug was active. These findings suggest that psilocybin has a low addiction potential and may be safe for therapeutic use in treating mental health conditions.

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The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts

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Different recipes made from Ganoderma lucidum mushroom have different health benefits. This study tested two recipes in mice and found that one (PGB) was better for reducing fatigue and improving exercise performance, while the other (GBS) was better for improving sleep quality. The research shows that how you prepare and combine medicinal mushroom ingredients matters for what health benefits you get.

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Neutral Polysaccharides From Hohenbuehelia serotina With Hypoglycemic Effects in a Type 2 Diabetic Mouse Model

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Researchers extracted and studied special compounds called polysaccharides from H. serotina mushrooms. They found that these compounds significantly reduced blood sugar levels in mice with type 2 diabetes and also protected the liver. The study shows that mushroom polysaccharides could be a safe, natural alternative to existing diabetes medications with fewer side effects.

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Efficacy of Rezafungin on Candida albicans Endophthalmitis in a Rabbit Model

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Researchers tested a new antifungal medication called rezafungin to treat a serious eye infection caused by the fungus Candida albicans. Using rabbit models, they found that rezafungin was much more effective than two other antifungal drugs at clearing the infection from the eye and preventing damage to vision. The drug’s ability to work for longer periods with less frequent dosing makes it a promising candidate for treating this devastating infection in patients.

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