Research Keyword: AKT signaling

Lentinan inhibits colorectal cancer stemness by binding CD133 and suppressing the CD133/p85/p-AKT signaling axis

Researchers discovered that lentinan, a natural compound from shiitake mushrooms, can specifically target and kill cancer stem cells in colorectal cancer by binding to a protein called CD133. This is significant because cancer stem cells are the reason why cancers come back even after treatment. By blocking a specific pathway these cells use to survive, lentinan may help prevent cancer recurrence and reduce the side effects associated with traditional chemotherapy.

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Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism

Researchers studied chaga mushroom (Inonotus obliquus) and found it helps muscles grow stronger and regenerate better. When mice were given chaga extract, their muscles became larger and stronger after injury, particularly through increased energy production in muscle cells. The mushroom works by activating specific proteins that promote muscle growth and boost the mitochondria (the energy factories) in muscle cells, suggesting it could help prevent age-related muscle weakness.

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