Research Keyword: acute liver failure

Ganoderma lingzhi (Reishi Mushroom)-Induced Acute Liver Injury in the Setting of Alcohol Use: A Case Report and Review of the Literature

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A 47-year-old man developed severe liver inflammation after consuming Reishi mushroom powder while drinking large amounts of vodka over three days. Although Reishi mushrooms are commonly promoted as healthy supplements, in this case the combination with alcohol caused his liver enzymes to spike dangerously high. The patient recovered after hospital treatment, but the case highlights that even natural supplements can be harmful, especially when combined with alcohol. This raises concerns that more research is needed on how mushroom supplements interact with other substances people consume.

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Clinical significance and outcomes of adult living donor liver transplantation for acute liver failure: a retrospective cohort study based on 15-year single-center experience

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Researchers studied 267 patients with acute liver failure over 15 years to compare two types of liver transplants: using living donors versus deceased donors. Living donor transplants worked just as well as deceased donor transplants, with similar patient survival rates, but allowed faster surgery before patients became critically ill. When a suitable living donor was available, performing the transplant quickly before severe brain complications developed led to better patient outcomes.

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Acute liver failure caused by Amanita verna: a case series and review of the literature

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This case study examines three patients who became severely ill after eating poisonous Amanita verna mushrooms in China. One patient successfully received a liver transplant and recovered, while the other two died from brain bleeding complications. The study highlights that liver transplantation can be life-saving for mushroom poisoning victims with severe liver failure, though doctors need better guidelines to decide when transplantation is the right choice.

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Educational Case: Acetaminophen hepatotoxicity: Pathophysiology and evaluation of acute liver failure

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This educational case describes how acetaminophen overdose causes severe liver damage leading to acute liver failure. The toxic form of acetaminophen damages liver cell mitochondria and causes widespread cell death, particularly in the center of liver lobules. Treatment with N-acetylcysteine within 24 hours of overdose significantly improves outcomes, though severe cases require liver transplantation.

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Herbal Supplement-Induced Liver Injury: A Case Report

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A 45-year-old woman developed severe liver injury after drinking an herbal tea containing multiple ingredients, including reishi mushroom and aloe vera. Her liver function gradually improved after she stopped drinking the tea, with complete recovery within three months. This case demonstrates that herbal supplements, often perceived as safe, can cause serious liver damage and should be investigated when patients develop unexplained liver problems.

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Therapeutic Plasma Exchange in Acute Liver Failure: A Real-World Study in Mexico

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Acute liver failure is a serious medical emergency where the liver suddenly stops working properly. This study found that a treatment called therapeutic plasma exchange (TPE), which filters the blood to remove harmful substances, significantly improved survival rates in liver failure patients treated in a Mexican hospital. Patients receiving TPE had a 92% survival rate at 30 days compared to only 50% in those receiving standard treatment alone, even though the TPE group had more severe cases at the start.

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Increasing incidence of mycotoxicosis in South-Eastern Germany: a comprehensive analysis of mushroom poisonings at a University Medical Center

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This study examined mushroom poisoning cases in a German hospital from 2005 to 2022 and found that poisonings have nearly doubled in recent years, likely due to more people foraging for wild mushrooms and changes in climate affecting mushroom distribution. The death cap mushroom (Amanita phalloides) caused the majority of serious cases, leading to liver and kidney failure. Researchers found that a blood-cleansing treatment called plasmapheresis could help stabilize patients with life-threatening bleeding complications while they recovered or waited for a liver transplant.

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