Research Keyword: β-catenin

rFIP-GMI Suppresses IGF-1–Induced Invasion and Migration in Breast Cancer Cells via PI3K/Akt/β-Catenin Inhibition

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Researchers found that a protein from a medicinal mushroom called Ganoderma microsporum can fight aggressive breast cancer by blocking a cellular pathway that helps cancer cells spread. The protein works by stopping the activation of key molecules (PI3K and Akt) that cancer cells use to invade surrounding tissues and migrate to other parts of the body. By blocking this pathway, the mushroom protein also prevents another molecule called β-catenin from entering the cell nucleus, where it would trigger genes that promote cancer growth and spread.

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Anticancer Activity of Demethylincisterol A3 and Related Incisterol-Type Fungal Products

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This review examines a special group of fungal compounds called incisterols, with focus on demethylincisterol A3 (DM-A3), which shows promise as a cancer-fighting agent. DM-A3 works through multiple mechanisms: it blocks cancer cell growth pathways, inhibits specific cancer-promoting proteins, and has anti-inflammatory effects. The compound has shown strong activity against various cancer types in laboratory and animal studies, making it a candidate for further development as a potential cancer therapy.

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Axin2 coupled excessive Wnt-glycolysis signaling mediates social defect in autism spectrum disorders

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Autism spectrum disorder affects social abilities in millions of people, but the underlying causes remain poorly understood. This research discovered that in the brains of people with autism, certain cellular processes that control energy and signaling become overactive, particularly in the region controlling social behavior. The good news is that the researchers found a drug-like compound called XAV939 can restore normal function by blocking the abnormal interaction between two key proteins, potentially offering a new treatment approach.

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Polysacharide of Agaricus blazei gel mitigates bone necrosis in model of the jaws related to bisphosphonate via Wnt signaling

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This study tested whether a gel made from Agaricus blazei mushroom could help repair jaw bone damage caused by bisphosphonate medications (used to treat bone loss). Using a rat model, researchers found that the mushroom gel significantly improved bone healing by activating biological pathways that promote bone-forming cell growth and activity. The treatment increased the number of living bone cells, improved bone quality, and reduced bone death and tissue damage. These promising results suggest the mushroom extract could become a helpful treatment to prevent or manage jawbone damage in patients taking bisphosphonate medications.

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