Trichophytosis – mycolab.ai

SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis

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Researchers studied a fungal protease called SUB6 produced by common skin infection-causing fungi. Using engineered fungi lacking this protein, they found that SUB6 helps fungi initially stick to skin but isn’t absolutely required for infection. The fungi can compensate by producing other proteases, suggesting SUB6 might be better used as a diagnostic marker to detect fungal infections rather than as a drug target.

Rediscovery of viomellein as an antibacterial compound and identification of its biosynthetic gene cluster in dermatophytes

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Researchers discovered that dermatophytes, fungi that cause common skin infections like athlete’s foot, produce a red pigment called viomellein that kills bacteria. By studying the genes responsible for making this compound, scientists found that most dermatophytes produce it, which may help explain how these fungi establish infections on skin despite the presence of protective bacteria. This discovery opens new possibilities for understanding skin infections and potentially developing new treatments.

Disease: Trichophytosis

SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis

Rediscovery of viomellein as an antibacterial compound and identification of its biosynthetic gene cluster in dermatophytes