Disease: tinea pedis

The association of Yarrowia lipolytica with onychomycosis

A 20-year-old woman suffered from a persistent toenail infection that didn’t respond to several standard antifungal treatments over five years. Researchers identified the culprit as Yarrowia lipolytica, a rare yeast not previously known to cause nail infections. Testing showed this yeast was resistant to common antifungal medications the patient had received, explaining why previous treatments failed. This unusual case highlights the importance of properly identifying fungal pathogens and testing them for drug resistance before starting treatment.

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Safety and efficacy of the swift microwave device in patients with mild-to-moderate onychomycosis: Protocol of an open-label, randomized, dose-finding pilot study

Onychomycosis, commonly known as toenail fungus, is a widespread infection affecting millions of people. Current treatments often fail or cause side effects. This study tests a new microwave device that heats the infected nail to kill the fungus without harming surrounding tissue or causing systemic side effects. Researchers are testing three different treatment schedules to find the most effective approach.

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Identification of Challenging Dermatophyte Species Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

This study shows that a specialized technique called MALDI-TOF mass spectrometry can accurately identify fungal skin infections by analyzing protein patterns. Researchers created a customized library of local fungal species that, when combined with commercial databases, improved identification accuracy from 16% to 91%. This advancement helps doctors quickly identify the exact type of fungal infection patients have, enabling faster and more appropriate treatment decisions.

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Northwest Iranian dermatophyte isolates: anthropophilic and geophilic

Researchers in northwestern Iran studied fungal infections of skin, hair, and nails by identifying different types of dermatophytes from patient samples and soil. They found that a fungus called Trichophyton mentagrophytes was the most common cause, but also discovered a rare fungus called Myriodontium keratinophilum causing nail infections. Using modern DNA testing methods, they identified seven different dermatophyte species and several other soil fungi, providing important information about fungal infections in this region.

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Superficial Fungal Infections in the Pediatric Dermatological Population of Northern Poland

This study examined fungal skin infections in children and teens in Northern Poland over six years, finding that about 1 in 5 children tested had a fungal infection. Different types of fungal infections were more common at different ages—younger children more often had scalp infections, while teenagers more often had foot and nail infections. The study found that children living in rural areas had higher infection rates than those in cities, suggesting that environmental factors play an important role in fungal infection patterns.

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Epidermophyton floccosum, an etiological agent of tinea pedis and tinea unguium: about two cases

Two elderly patients with toenail and foot fungal infections caused by Epidermophyton floccosum were diagnosed using modern molecular testing methods. Traditional microscopic examination alone was difficult, but real-time PCR provided accurate identification. Both patients were treated with terbinafine, a common antifungal medication. The study highlights how modern DNA testing improves diagnosis compared to older methods.

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Antifungal susceptibility testing of Microsporum canis isolated from the skin of dermatologically healthy cats

Researchers tested healthy cats in Chile and found that about 5% carried a fungus called Microsporum canis that can cause ringworm. This fungus was resistant to a common antifungal drug called fluconazole. Indoor cats were more likely to carry the fungus than outdoor cats. Because cats can spread this fungus to people, identifying carrier cats is important for preventing human infections.

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Superficial Fungal Infections in the Pediatric Dermatological Population of Northern Poland

This study examined fungal skin infections in children and teenagers in northern Poland from 2019 to 2024. Researchers tested over 1,200 young patients and found that about 1 in 5 had a fungal infection. The most common culprits were specific fungi that cause scalp infections in young children and foot/nail infections in teenagers. Interestingly, children living in rural areas were more likely to have these infections, even though more urban children were tested.

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Superficial Fungal Infections in Children—What Do We Know?

Fungal infections of the skin, hair, and nails are increasingly common in children worldwide, especially in warm, humid climates and in crowded living conditions. These infections are caused by germs that live on the skin and can spread through contact with infected people or animals. Children are particularly vulnerable due to their developing immune systems, but most infections are treatable with topical creams or oral medications, with terbinafine being the most effective option currently available.

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PCR enables rapid detection of dermatophytes in practice

Researchers in Finland studied how a fast DNA test (PCR) can detect fungal skin infections better than traditional slow culture methods. The new test, called DermaGenius, gives results in just 16 hours instead of 19 days. By 2022, most fungal infection samples were tested using this faster method, which helps doctors treat patients quickly without unnecessary medications.

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