Temporal lobe epilepsy

Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ- and MES-Induced Seizures in Mice via 5-HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways

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Researchers tested psilocin, the active ingredient in magic mushrooms, and found it could reduce seizures in mice at low doses (3-5 mg/kg) without causing psychedelic effects. The anticonvulsant benefits were mediated through several brain pathways including serotonin, cannabinoid, opioid, and nitric oxide signaling systems. The effects persisted for at least 9 days after a single dose, suggesting psilocin may have potential as a new treatment for epilepsy, though human clinical trials are needed to confirm these findings.

A review of the neuroscience of religion: an overview of the field, its limitations, and future interventions

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This review examines how neuroscience studies the brain’s role in religious experiences and behaviors. While current brain imaging technology has revealed connections between specific brain regions and religious practices like prayer and meditation, these technologies limit what researchers can study because they require people to stay still. The authors suggest that newer technologies like functional near-infrared spectroscopy could allow scientists to study the full range of religious behaviors, including movement-based rituals that are important to many faiths.

Adaptation and latent structure of the Brazilian version of the Ego Dissolution Inventory (EDI-BR): an exploratory study

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This study adapted a psychological assessment tool called the Ego Dissolution Inventory for use in Brazil. Ego dissolution refers to the profound sense of losing one’s sense of self that people experience when using psychedelics like psilocybin mushrooms and LSD. The researchers found that the adapted Brazilian version works well and identifies three dimensions of the experience: confidence/assertiveness, ego dissolution, and ego inflation. This validated tool can now help researchers in Brazil better understand psychedelic experiences and their potential therapeutic benefits.

Disease: Temporal lobe epilepsy

Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ- and MES-Induced Seizures in Mice via 5-HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways

A review of the neuroscience of religion: an overview of the field, its limitations, and future interventions

Adaptation and latent structure of the Brazilian version of the Ego Dissolution Inventory (EDI-BR): an exploratory study