Disease: systemic fungal diseases

Assessing the Validity and Impact of Remote Digital Image Reading in Fungal Diagnostics

This study tested whether trained mycologists could accurately identify fungal infections from digital images viewed remotely, similar to how radiologists review X-rays. Five experienced laboratory professionals analyzed 474 images of different fungi with accuracy rates between 78-93%. The results suggest that remote digital diagnosis could help hospitals in developing countries where expert mycologists are scarce, enabling faster and more accurate diagnosis of serious fungal infections.

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Improving the production of micafungin precursor FR901379 in Coleophoma empetri using heavy-ion irradiation and its mechanism analysis

Researchers used heavy-ion radiation to create improved strains of a fungus that produces a precursor to micafungin, an important antifungal drug. The improved strains produced over 3.5 times more of the desired compound than the original strain. By analyzing the genetic changes in these improved strains, the scientists identified which genes were most important for boosting production, helping guide future improvements in manufacturing this life-saving medicine.

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