Disease: stress-related disorders

Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics

This review examines how psychedelic substances like psilocybin and LSD affect brain structure and function. Research shows these compounds can increase BDNF (a protein crucial for brain health) and promote the growth of new neurons and connections between brain cells. These biological changes may explain why psychedelics have shown promise in treating depression and anxiety, with effects lasting weeks after a single dose.

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The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study

This study examined whether Lion’s mane mushroom supplements could improve thinking speed and reduce stress in healthy young adults. Researchers found that a single dose improved how quickly people completed a mental challenge, and four weeks of daily supplements showed a trend toward reducing subjective stress. However, the study was small and found mixed results, including some negative effects on memory tasks, so more research with larger groups is needed to confirm these findings.

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Exploring Molecular Changes in the Extended Amygdala Induced by Chronic Corticosterone Administration

Researchers studied how prolonged stress hormone exposure affects the brain’s emotional center in mice. They found that chronic corticosterone treatment caused depression-like behaviors and specific molecular changes in different parts of the amygdala, a brain region crucial for processing emotions. These findings help explain how chronic stress disrupts the brain’s normal stress-regulation system and contributes to depression and other psychiatric conditions.

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