Sepsis – mycolab.ai

Heavy Metal Poisoning and Its Impacts on the Conservation of Amazonian Parrots: An Interdisciplinary Review

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Amazonian parrots face a serious but often invisible threat from heavy metal poisoning caused by illegal mining, agriculture, and urban waste. These toxic metals accumulate in the birds’ bodies over their long lifespans, causing brain damage, kidney failure, and reproductive problems that threaten entire parrot populations. The review calls for urgent action including stopping illegal mining, cleaning contaminated areas, and protecting forests to ensure these important seed-dispersing birds survive.

The Role of Plant Extracts in Enhancing Nutrition and Health for Dogs and Cats: Safety, Benefits, and Applications

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This review examines how plant-based supplements like tea extracts, curcumin, and quercetin can improve the health of pet dogs and cats. These natural compounds act as antioxidants and anti-inflammatory agents, supporting gut health, immune function, and overall wellness in companion animals. While generally safe when properly dosed, cats and dogs metabolize these compounds differently, requiring species-specific dosing strategies to maximize benefits and minimize risks.

Diagnostic Approaches to Invasive Candidiasis: Challenges and New Perspectives

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Invasive candidiasis is a serious fungal infection affecting critically ill patients in hospitals. Current testing methods like blood cultures are slow and sometimes miss the infection. Researchers are developing faster diagnostic tests using DNA detection and biomarkers that can identify infections within hours instead of days, allowing doctors to start treatment sooner and save more lives.

The Prognostic Value of (1→3)-β-D-Glucan in COVID-19 Patients with and Without Secondary Fungal Disease

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During COVID-19 infection, a fungal marker called beta-D-glucan (BDG) in the blood can predict patient survival even without a diagnosed fungal infection. Researchers found that COVID-19 patients with high BDG levels had a 91% death rate if not treated with antifungal drugs, but this dropped to 50% when antifungal therapy was given. The high BDG levels trigger a strong inflammatory response in the body that worsens disease severity, making BDG a valuable warning sign for doctors treating critically ill COVID-19 patients.

mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease

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This review examines how serious infections (sepsis) from bacteria and fungi affect people with advanced HIV disease, particularly in hospitals. The infections have become more dangerous due to antimicrobial resistance, and many cases go undiagnosed because of limited laboratory capabilities. The paper calls for better diagnostic tools and treatment strategies tailored to resource-limited settings where most advanced HIV disease cases occur.

Time- and temperature-dependent Pentraxin 3 stability in serum and bronchoalveolar lavage fluid samples

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Pentraxin 3 is a protein marker that helps doctors detect serious fungal infections. This study tested how well this marker stays stable in blood and lung fluid samples when stored at different temperatures over long periods. The results show that samples should be kept frozen at −20°C or −80°C to preserve the marker, but samples left at room temperature or warmer are quickly damaged and unreliable for testing.

Time- and temperature-dependent Pentraxin 3 stability in serum and bronchoalveolar lavage fluid samples

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Researchers tested how well Pentraxin 3, a protein that helps detect fungal infections, stays stable when stored under different conditions. They found that this protein remains reliable when kept frozen at cold temperatures (like in a freezer) for up to several months or even years, but breaks down quickly when stored at body temperature. These findings help doctors and laboratories know how to properly store and test patient samples to accurately diagnose serious fungal infections.

Identification of fungal agents isolated from burn lesions using mycological and molecular methods in patients admitted to Velayat burn hospital in Rasht city during 2022–2023

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Researchers studied fungal infections in burn patients at a hospital in Iran and found that non-albicans Candida fungi, particularly a species called Candida parapsilosis, were the most common culprits. Using laboratory cultures and genetic testing, they identified 101 fungal infections out of 380 burn patients. Understanding which fungi cause these infections is important for doctors to choose the right treatment and improve patient outcomes.

Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

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Researchers studied fungal infections in urine samples from hospitalized patients and found that while the common yeast Candida albicans was most prevalent, other Candida species were increasingly resistant to antifungal medications. Using advanced genetic testing methods, they identified seven different Candida species and tested their resistance to three common antifungal drugs. The findings highlight the growing problem of drug-resistant fungal infections and the need for better diagnostic tools to identify which species is causing infection so appropriate treatment can be selected.

A rare case of invasive necrotizing myositis of the thigh caused by Basidiobolus ranarum: a multi-pronged approach to successfully managing a near-fatal polybacterial mycotic infection

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A 46-year-old man developed a severe fungal infection caused by a rare fungus called Basidiobolus ranarum in his thigh, which started from an insect bite two years earlier. The infection caused tissue death and was complicated by bacterial superinfection, requiring aggressive treatment with multiple antibiotics and antifungal medications along with several surgeries. Doctors used a combination approach including voriconazole, potassium iodide, and itraconazole to finally control the infection, though amputation was necessary due to the extent of tissue damage. The case highlights the importance of early medical care and demonstrates that rare fungal infections can be life-threatening even in otherwise healthy people.

Disease: Sepsis