Rice sheath blight disease

Cinchona-based liquid formulation exhibits antifungal activity through Tryptophan starvation and disruption of mitochondrial respiration in Rhizoctonia Solani

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Researchers found that an extract from Cinchona bark, containing the compound quinine, effectively kills rice-damaging fungus Rhizoctonia solani through two mechanisms: starving the fungus of the amino acid tryptophan and disrupting its energy-producing mitochondria. This natural plant-based treatment could serve as an eco-friendly alternative to synthetic fungicides, reducing crop losses from fungal diseases while avoiding the environmental damage and resistance problems associated with chemical pesticides.

Cinchona-based liquid formulation exhibits antifungal activity through Tryptophan starvation and disruption of mitochondrial respiration in Rhizoctonia Solani

mycolabadmin

Scientists tested a plant-based extract from Cinchona bark as a natural fungicide against a serious fungus that damages rice crops. The active ingredient, quinine, works by two methods: it blocks the fungus from getting the amino acid tryptophan it needs to survive, and it damages the fungus’s energy-producing structures. When researchers added tryptophan back to the treated fungus, it recovered, confirming this is how the treatment works. This natural fungicide could offer farmers an eco-friendly alternative to chemical pesticides.

Cinchona-based liquid formulation exhibits antifungal activity through Tryptophan starvation and disruption of mitochondrial respiration in Rhizoctonia Solani

mycolabadmin

Scientists discovered that a liquid extract from Cinchona bark, which contains quinine, can effectively kill a fungus that damages rice crops. The treatment works by blocking the fungus’s ability to absorb tryptophan (an important amino acid) and damaging its energy-producing mitochondria. When tryptophan was added back to the treatment, the fungus recovered, confirming this is the main way the extract works. This natural, plant-based approach could provide an eco-friendly alternative to chemical fungicides while reducing the risk of the fungus developing resistance.

Revisiting the emerging pathosystem of rice sheath blight: deciphering the Rhizoctonia solani virulence, host range, and rice genotype-based resistance

mycolabadmin

Rice plants are affected by a fungal disease called sheath blight caused by a fungus named Rhizoctonia solani. This study found that different strains of this fungus vary in how aggressive they are, with some being much more damaging than others. By testing various rice varieties, researchers identified which ones naturally resist this disease better, and these resistant varieties could be used to breed new rice crops that are less affected by the disease.

Disease: Rice sheath blight disease

Cinchona-based liquid formulation exhibits antifungal activity through Tryptophan starvation and disruption of mitochondrial respiration in Rhizoctonia Solani

Cinchona-based liquid formulation exhibits antifungal activity through Tryptophan starvation and disruption of mitochondrial respiration in Rhizoctonia Solani

Cinchona-based liquid formulation exhibits antifungal activity through Tryptophan starvation and disruption of mitochondrial respiration in Rhizoctonia Solani

Revisiting the emerging pathosystem of rice sheath blight: deciphering the Rhizoctonia solani virulence, host range, and rice genotype-based resistance