rhino-orbital cerebral mucormycosis

Pathogenic mucorales: Deciphering their cell wall polysaccharidome and immunostimulatory potential

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Researchers studied three dangerous fungi that cause serious infections called mucormycosis. They examined the outer coating of these fungi, called the cell wall, which is made of sugar-like molecules called polysaccharides. When these fungi were exposed to human immune cells, they triggered strong inflammatory responses. Understanding these fungal components could help develop better treatments and vaccines for this life-threatening infection.

Odontogenic-onset mucormycosis: A case series from a tertiary care institute in North India

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This case series describes five patients from India who developed a serious fungal infection in their jaw and mouth after dental procedures. All patients had uncontrolled diabetes, which weakened their immune system and allowed the fungus to grow. The infection was treated with anti-fungal medications and surgery, and most patients recovered well. The study emphasizes the importance of keeping dental equipment sterile and managing blood sugar levels properly before dental work.

A Rare Battle: Multidisciplinary Care for a Child with Rhino-Orbital Cerebral Mucormycosis in Somali Region of Ethiopia

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A 12-year-old girl with poorly controlled diabetes developed a serious fungal infection in her sinuses and eye that spread to her brain. Despite the infection being extremely dangerous, doctors successfully treated her using multiple approaches including antifungal medication, surgery to remove infected tissue, and careful management of her blood sugar. She recovered and went home, though she lost vision in one eye.

The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis

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This study evaluated how well PCR blood tests and tissue samples can diagnose a serious fungal infection called mucormycosis. Researchers analyzed 30 previous studies and found that PCR testing works very well, especially on respiratory fluid samples. Blood tests showed good accuracy too and could be useful for screening high-risk patients without requiring invasive procedures. The findings suggest PCR should become a standard diagnostic method for this difficult-to-diagnose infection.

Odontogenic-onset mucormycosis: A case series from a tertiary care institute in North India

mycolabadmin

Mucormycosis is a serious fungal infection that can develop after dental procedures like tooth extraction or root canal therapy, especially in people with poorly controlled diabetes. This case study from India describes five patients who developed this infection within weeks of dental work. The infection destroys bone in the upper jaw and palate but usually doesn’t spread to the sinuses like other forms of mucormycosis. All patients improved with antifungal medications and surgical cleaning, highlighting the importance of proper sterilization during dental procedures.

The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis

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Mucormycosis is a dangerous fungal infection that kills many patients. Traditional tests like fungal culture are slow and often miss infections. This comprehensive study of 30 research papers shows that PCR testing is very effective at detecting this fungus, with different specimen types having different success rates. Blood tests were easiest to perform and worked well for screening high-risk patients, while fluid from the lungs was the most accurate.

Clinical Challenges and Predictive Risk Factors for Outcomes in COVID-19–Associated Mucormycosis

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During the COVID-19 pandemic, a dangerous fungal infection called mucormycosis has become a serious complication, especially for patients with uncontrolled diabetes or those taking certain medications. Researchers studied 180 patients with this condition and found that the infection can spread from the sinuses to the eyes and brain, leading to severe outcomes. The most important factors in surviving this infection are early detection, keeping blood sugar controlled, careful use of steroids, and aggressive treatment with antifungal medications and sometimes surgery.

Rhino-orbital-cerebral mucormycosis in diabetic ketoacidosis: A classic clinical presentation still unknown in Senegal

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A young woman in Senegal with uncontrolled diabetes developed a serious fungal infection affecting her eye and brain caused by Rhizopus oryzae. Despite showing classic warning signs like swelling and tissue death, the infection was not diagnosed quickly enough, and the necessary antifungal medication (amphotericin B) was not available, resulting in her death within three days. This case highlights how invasive fungal infections are underrecognized and undertreated in Africa due to limited laboratory capacity and drug availability.

Disease: rhino-orbital cerebral mucormycosis