Rhino-orbital-cerebral infection

The Rising Threat of Mucormycosis: Oman’s Experience Before and During the COVID-19 Pandemic

mycolabadmin

Mucormycosis is a serious fungal infection that became much more common in Oman during the COVID-19 pandemic. Most patients had diabetes and nearly half had COVID-19, with very high death rates. The infection primarily affects the sinuses and brain, and requires aggressive treatment with surgery and antifungal medications. This study shows doctors need better tools to detect and treat this dangerous infection, especially during health crises.

The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis

mycolabadmin

This study reviews how well a molecular test called PCR can diagnose mucormycosis, a dangerous fungal infection. Researchers analyzed 30 studies covering over 5,000 patient samples and found that PCR works very well for detecting this infection, especially when using samples from the lungs. Blood tests were also effective but slightly less sensitive. The study recommends using PCR as part of updated diagnostic guidelines to help doctors catch this serious infection earlier, potentially improving patient outcomes.

Molecular epidemiology, diversity, and antifungal susceptibility profiles of clinical and environmental mucorales: a five-year multicenter study in Iran (2018–2023)

mycolabadmin

This research examined dangerous mold infections (Mucormycosis) that became more common after COVID-19. Scientists identified the types of molds causing these infections in Iran by testing 116 patient samples and 65 soil samples from across the country. They tested these molds against 13 different antifungal medications to find which drugs work best. The results showed that amphotericin B and posaconazole were the most effective medications, and patient samples were more susceptible to these drugs than environmental soil samples.

Pathogenic mucorales: Deciphering their cell wall polysaccharidome and immunostimulatory potential

mycolabadmin

Mucormycosis is a serious fungal infection that primarily affects people with weak immune systems and carries high mortality rates. Researchers studied three common mucormycosis-causing fungi to understand how their outer cell layers interact with the human immune system. They found that all three fungi trigger strong inflammatory responses, which may explain why the disease is so damaging. This research helps us better understand how these infections work and could lead to improved treatments or vaccines.

Detection of Mucorales antigen in bronchoalveolar lavage samples using a newly developed lateral-flow device

mycolabadmin

Researchers developed and tested a new rapid test (TG11-LFD) for detecting mucormycosis, a dangerous fungal infection, using a simple device similar to a COVID rapid test. The test detects a specific protein marker released by Mucorales fungi in lung fluid samples. In testing with 62 clinical samples, the new test correctly identified about 77% of actual infections and was negative in about 76% of non-infected samples. This affordable, simple test could help doctors quickly diagnose mucormycosis and start life-saving treatment faster, especially in countries with limited laboratory resources.

Molecular epidemiology, diversity, and antifungal susceptibility profiles of clinical and environmental mucorales: a five-year multicenter study in Iran (2018–2023)

mycolabadmin

This study examined dangerous mold infections called mucormycosis that became more common during the COVID-19 pandemic, particularly in Iran. Researchers tested over 180 fungal samples from patients and soil to understand which types of molds cause infections and which antifungal medicines work best against them. They found that two medicines, amphotericin B and posaconazole, were most effective, while fungi from soil samples were often more resistant to treatment than those from infected patients. This research helps doctors choose the right treatments for patients with these serious infections.

Disease: Rhino-orbital-cerebral infection

The Rising Threat of Mucormycosis: Oman’s Experience Before and During the COVID-19 Pandemic

The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis

Molecular epidemiology, diversity, and antifungal susceptibility profiles of clinical and environmental mucorales: a five-year multicenter study in Iran (2018–2023)

Pathogenic mucorales: Deciphering their cell wall polysaccharidome and immunostimulatory potential

Detection of Mucorales antigen in bronchoalveolar lavage samples using a newly developed lateral-flow device

Molecular epidemiology, diversity, and antifungal susceptibility profiles of clinical and environmental mucorales: a five-year multicenter study in Iran (2018–2023)