rheumatoid arthritis

Edible mushrooms as emerging biofactories for natural therapeutics and oral biopharmaceutical delivery

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Mushrooms are emerging as natural medicine factories that can be genetically engineered to produce medications taken by mouth. Beyond their traditional use as health foods, scientists are now using advanced genetic techniques to program mushrooms to manufacture therapeutic proteins and vaccines. These engineered mushrooms can naturally package and protect these medications as they pass through the stomach, releasing them safely in the intestines for absorption. This approach offers a sustainable, affordable, and cold-chain-independent alternative to conventional injected medications.

Regulatory effects of Lycium Barbarum polysaccharides on immune function and their application prospects

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Lycium barbarum, a plant used in traditional Chinese medicine for over 2000 years, contains special compounds called polysaccharides that boost the immune system. These compounds work by activating immune cells like macrophages and T cells, and can help fight infections and reduce inflammation. Research shows they may also help with conditions like arthritis, cancer, and gut health by acting as a natural prebiotic that promotes beneficial bacteria.

Gut Microbiome and Immune System Crosstalk in Chronic Inflammatory Diseases: A Narrative Review of Mechanisms and Therapeutic Opportunities

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Your gut contains trillions of bacteria that play a crucial role in keeping your immune system balanced. When this bacterial community becomes imbalanced (dysbiosis), it can lead to chronic inflammatory diseases like arthritis, inflammatory bowel disease, psoriasis, and lupus. Recent research shows that restoring a healthy gut microbiota through diet, probiotics, prebiotics, or fecal transplants may help treat these conditions by reducing inflammation and strengthening the gut barrier.

Vinigrol Tricyclic Scaffold Biosynthesis Employs an Atypical Terpene Cyclase and a Multipotent Cyclization Cascade

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Scientists have discovered how a fungus produces vinigrol, a complex molecule with potential health benefits including lowering blood pressure and reducing inflammation. Using advanced computational tools and genetic engineering, researchers identified the specific genes and enzymes the fungus uses to build this molecule’s intricate three-ring structure. By modifying a key enzyme, they were able to create an entirely new diterpene molecule that doesn’t exist in nature, demonstrating the potential to engineer biological systems to produce novel medicinal compounds.

Sensory Characteristics of Probiotic-Containing Foods: A Multidisciplinary Perspective on Enhancing Acceptability and Consumer Adherence

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This review explains why we don’t eat probiotic foods regularly even though we know they’re healthy: they often don’t taste, smell, or feel good. The authors show that improving the taste, texture, and appearance of probiotic foods can help people stick with them. They discuss how using different bacterial strains, better food formulas, and clever cooking techniques can make these foods more enjoyable while keeping their health benefits intact.

Isolation Techniques, Structural Characteristics, and Pharmacological Effects of Phellinus Polysaccharides: A Review

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This review examines how scientists extract and study beneficial compounds called polysaccharides from a medicinal fungus called Phellinus. These polysaccharides show promise in fighting cancer, reducing inflammation, and boosting immune function. Different extraction methods affect the quality and effectiveness of these compounds, and researchers are working to optimize these techniques for better therapeutic applications.

Plant and Fungal Polysaccharides in Periodontitis Treatment: Diverse Mechanisms and Therapeutic Roles

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Periodontitis is a serious gum disease that causes tooth loss and affects overall health. This review examines how polysaccharides (complex carbohydrates) from plants and fungi can help treat periodontitis by reducing inflammation, fighting bacteria, and helping gum tissue repair. These natural compounds work through multiple biological pathways to improve oral health outcomes while avoiding the side effects and resistance problems associated with conventional drugs.

Detection of Opportunistic Fungi from the Bronchoalveolar Lavage Specimens of Patients with Pulmonary Diseases

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Researchers examined lung fluid samples from patients with lung diseases to identify fungal infections. They found various types of fungi including Aspergillus, Penicillium, and Pneumocystis using microscopy and laboratory tests. Large numbers of fungi were present in many samples, which could interfere with medicine absorption and treatment. The study shows that quick and accurate identification of these fungi is important for treating lung infections properly.

Isolation, identification and antibacterial activity of endophytes from the seeds of Panax japonicus

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This study investigated microscopic organisms living inside Panax japonicus seeds to understand why these seeds are difficult to grow. Researchers found the best way to clean the seeds and identified ten different microorganism species living in them. Most of these were fungi that may actually prevent seed germination, while certain bacteria species appear beneficial for plant growth and could potentially be used to improve seed cultivation in the future.

The Effect of Natural-Based Formulation (NBF) on the Response of RAW264.7 Macrophages to LPS as an In Vitro Model of Inflammation

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Researchers tested a natural mixture of five medicinal mushrooms combined with cannabidiol (CBD) on immune cells exposed to bacterial endotoxins. The formulation effectively reduced inflammatory response markers without harming the cells. These findings suggest the mixture could potentially be used to treat inflammatory conditions like asthma and arthritis, though more research is needed.

Disease: rheumatoid arthritis