Disease: psoriasis

Production of fungal hypocrellin photosensitizers: Exploiting bambusicolous fungi and elicitation strategies in mycelium cultures

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Hypocrellins are powerful compounds from fungi that can treat cancers and infections through light-activated therapy. Since wild sources are limited, scientists are growing these fungi in laboratory cultures and using special techniques to boost production. This review summarizes the best methods for producing hypocrellins, from choosing the right fungal strains to optimizing growing conditions and using natural stimulants to increase yields.

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Superficial Fungal Infections in Children—What Do We Know?

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Fungal infections of the skin, hair, and nails are increasingly common in children worldwide, especially in warm, humid climates and in crowded living conditions. These infections are caused by germs that live on the skin and can spread through contact with infected people or animals. Children are particularly vulnerable due to their developing immune systems, but most infections are treatable with topical creams or oral medications, with terbinafine being the most effective option currently available.

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Divergent Immunomodulatory Roles of Fungal DNA in Shaping Treg and Inflammatory Responses

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Different types of fungal DNA trigger different immune responses in the body. DNA from the common yeast Candida albicans promotes immune tolerance and protects T cells, similar to beneficial bacterial DNA. In contrast, DNA from the pathogenic fungus Cryptococcus neoformans triggers strong inflammatory immune responses. This discovery reveals that fungal DNA itself, not just fungal cell wall components, plays an important role in determining whether fungi are treated as friendly commensals or dangerous pathogens by the immune system.

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Etiological Agents and Predisposing Factors of Superficial Fungal Infections in Northeastern Argentina

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Researchers studied fungal skin infections in a community in northeastern Argentina, finding that 37% of patients had these infections. The most common cause was a fungus called Trichophyton tonsurans. Poor living conditions like overcrowding and lack of clean water increased infection risk. The study shows that fungal skin infections are a significant health problem in areas with limited access to basic sanitation and water services.

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