Disease: prosthetic valve endocarditis

Caspofungin therapy in prosthetic valve endocarditis and candidemia due to itraconazole-resistant Candida glabrata (Nakaseomyces glabratus): A case report

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A 13-year-old boy developed a serious fungal infection on his replacement heart valve after recent surgery. The fungal infection was caused by a type of yeast called Candida glabrata that was resistant to the initial antifungal medication. After testing revealed resistance and biofilm formation, doctors switched to caspofungin, a stronger antifungal drug, and the patient recovered successfully.

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Histoplasma capsulatum prosthetic valve endocarditis treated with oral isavuconazole

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A 76-year-old man developed a rare fungal infection of his artificial heart valve caused by Histoplasma capsulatum. After surgically replacing the infected valve, he was treated with isavuconazole, an antifungal medication taken by mouth. Unlike traditional antifungal treatments, isavuconazole was better tolerated and easier to take. The patient successfully recovered after nine months of treatment with no complications.

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Caspofungin therapy in prosthetic valve endocarditis and candidemia due to itraconazole-resistant Candida glabrata (Nakaseomyces glabratus): A case report

mycolabadmin

A 13-year-old boy developed a serious fungal infection of his heart valve after surgery. The infection was caused by a resistant yeast that didn’t respond to initial antifungal treatment. Doctors used molecular testing to identify the exact fungal species and tested how it responded to different medications. After switching to a different antifungal drug called caspofungin, the patient recovered completely and remained healthy.

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Favourable outcome of Fusarium prosthetic valve endocarditis in a patient with an Ebstein anomaly

mycolabadmin

A 26-year-old woman with a congenital heart condition (Ebstein anomaly) received a replacement heart valve. Six months later, a rare fungal infection caused by Fusarium developed on the new valve, leading to lung complications. Through a combination of surgery to remove the infected valve and antifungal medications, particularly voriconazole, the patient recovered successfully. This case demonstrates that even life-threatening fungal heart infections can be treated with proper surgical intervention and targeted medication.

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Caspofungin therapy in prosthetic valve endocarditis and candidemia due to itraconazole-resistant Candida glabrata (Nakaseomyces glabratus): A case report

mycolabadmin

A 13-year-old boy developed a serious fungal infection of his heart valve after receiving an artificial valve replacement. The initial antibiotic (itraconazole) did not work because the fungus became resistant, likely by forming a protective biofilm. After identifying the resistant fungus through specialized testing, doctors switched to a different medication called caspofungin. The patient fully recovered with this new treatment and remained healthy during follow-up, showing that combination of precise identification and targeted treatment can overcome antibiotic resistance.

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