Disease: Postpartum hemorrhage

Fungi: Pioneers of chemical creativity – Techniques and strategies to uncover fungal chemistry

This review explores how fungi produce remarkable chemical compounds that have been transformed into important medicines for over a century. Starting with penicillin in the 1940s, scientists have discovered dozens of fungal-derived drugs used to treat infections, prevent organ rejection, lower cholesterol, and fight cancer. Modern technology now allows researchers to discover and analyze these compounds much faster and with smaller samples than ever before.

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mGem: How many fungal secondary metabolites are produced by filamentous fungi? Conservatively, at least 1.4 million

Scientists have discovered about 30,000 fungal compounds with useful properties, from life-saving antibiotics like penicillin to cholesterol-lowering drugs. However, new research suggests that fungi actually produce somewhere between 1.4 million and 4.3 million different chemical compounds, meaning we’ve only discovered about 1-2% of what’s out there. By studying the genomes of fungi, researchers estimate that for every fungal medicine we know about, there could be 50-100 more waiting to be discovered, representing an enormous opportunity for developing new drugs and therapies.

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A case report of Saksenaea vasiformis mucormycosis infection of a lower segment caesarean section wound

A young woman developed a rare fungal infection (mucormycosis) in her caesarean section wound seven days after surgery. Despite initial antibiotic treatment, she required multiple surgical debridement procedures combined with antifungal medications to eliminate the infection. The surgical team successfully reconstructed her abdominal wall using specialized mesh and skin grafting techniques, resulting in complete healing.

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