Parkinson’s disease – Page 5

The Major Stilbene Compound Accumulated in the Roots of a Resistant Variety of Phoenix dactylifera L. Activates Proteasome for a Path in Anti-Aging Strategy

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Researchers found that date palm roots from disease-resistant varieties contain a special compound called 3,3′,4,5,5′-pentahydroxy-trans-stilbene that acts as a natural antioxidant and anti-aging agent. This compound can protect aging skin cells by activating the proteasome, which is like the cell’s recycling system that removes damaged proteins. The findings suggest this natural compound could potentially help slow down skin aging and protect against age-related diseases.

Natural Neuroinflammatory Modulators: Therapeutic Potential of Fungi-Derived Compounds in Selected Neurodegenerative Diseases

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This comprehensive review explores how compounds found in mushrooms could help treat serious brain diseases like Alzheimer’s and Parkinson’s disease. Mushrooms contain natural substances such as certain carbohydrates, proteins, and fats that can reduce harmful inflammation in the brain and protect nerve cells from damage. Scientists have tested these mushroom-derived compounds in laboratory and animal models, finding they can improve memory, movement, and overall brain function. This research suggests mushrooms could become an important part of new treatments for these currently incurable neurological conditions.

Proteins from Edible Mushrooms: Nutritional Role and Contribution to Well-Being

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Mushrooms are highly nutritious foods containing proteins as complete and high-quality as meat, with unique compounds that boost immunity, fight infections, and may help prevent diseases like cancer and diabetes. Different types of mushroom proteins have specific health benefits, from strengthening immune systems to lowering blood pressure and fighting viruses. Scientists are finding new ways to grow mushrooms and extract their proteins for use in sports nutrition, medicines, and fortified foods, making them increasingly valuable for human health and sustainability.

Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer’s disease through molecular dynamics simulation and MMGBSA

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Researchers used computer simulations to test five compounds from Reishi mushrooms against Alzheimer’s disease. They found that two compounds, ganoderic acid A and ganoderenic acid B, showed strong potential for blocking a harmful protein involved in the disease. These findings suggest Reishi mushrooms could be a source for new Alzheimer’s treatments, though further laboratory testing is needed.

N-terminal oligomerization drives HDAC4 nuclear condensation and neurodevelopmental dysfunction in Drosophila

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This study reveals how a protein called HDAC4 forms clumps inside cell nuclei, which damages brain development. Researchers found that the protein’s ability to stick to itself (oligomerize) drives this clumping process. By modifying the protein to prevent self-sticking, they reduced the damage to developing brain structures, suggesting new ways to treat brain disorders linked to HDAC4 accumulation.

Immunomodulatory natural polysaccharide-based nanoparticles for the treatment of neurodegenerative diseases

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Scientists are developing tiny particles made from natural sugar-based compounds that can deliver medicine to the brain while reducing inflammation caused by neurodegenerative diseases like Alzheimer’s and Parkinson’s. These nanoparticles are special because they can cross the protective barrier surrounding the brain and carry therapeutic compounds directly to where they’re needed. The natural polysaccharides used to make these particles have built-in anti-inflammatory properties, making them safer and more effective than traditional approaches. This innovative technology shows promise for treating currently difficult-to-manage brain diseases.

The Role of AFB1, OTA, TCNs, and Patulin in Forensic Sciences: Applications in Autopsy, Criminal Investigations, and Public Health Prevention

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This research examines how dangerous fungal poisons (mycotoxins) found in contaminated food can be detected in deceased individuals during autopsies. These toxins, produced by common molds, can cause serious health problems including liver cancer, kidney disease, and immune system damage. The study proposes procedures for forensic investigators to collect and analyze these toxins from body tissues and fluids to help solve cases involving poisoning or chronic toxin exposure.

Three Different Types of β-Glucans Enhance Cognition: The Role of the Gut-Brain Axis

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Researchers tested three types of β-glucans—fiber compounds found in mushrooms, oats, and other foods—to see if they could improve memory in mice. All three types enhanced recognition memory and reduced brain inflammation, while only oat β-glucan significantly changed gut bacteria composition. The findings suggest that different β-glucans may help prevent cognitive decline through different mechanisms involving the gut-brain connection.

Newly Discovered Fungal Species from Black Pepper Marketed in Brazil: Penicillium pipericola sp. nov. and Syncephalastrum brasiliense sp. nov.

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Researchers in Brazil discovered two new fungal species found on commercially sold black pepper. While one species can produce a toxic compound that concerns food safety experts, both species also produce molecules with potential medical benefits, including compounds that may help fight cancer and neurological diseases. This discovery highlights the importance of monitoring fungi in food products while also revealing unexpected pharmaceutical potential hidden in everyday spices.

Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons

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Researchers created mice with reduced ROCK2 protein in brain cells to understand how this protein affects behavior and brain structure. These mice showed anxiety-like behavior, avoiding open spaces and preferring darkness. The study found that ROCK2 affects the structure of dendritic spines, which are tiny branches on nerve cells that allow communication between neurons, particularly in the hippocampus region involved in learning and memory.

Disease: Parkinson's disease