Disease: Pancytopenia

Disseminated histoplasmosis with bone marrow infiltration in a newly diagnosed HIV patient

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A Colombian patient living in Spain developed a serious fungal infection (histoplasmosis) that spread throughout his body and affected his bone marrow, which was discovered during his HIV diagnosis. Doctors identified the infection by examining bone marrow cells under a microscope and confirmed it with fungal culture and genetic testing. The patient was treated with antifungal medication (liposomal amphotericin B) along with HIV medications and recovered well, highlighting the importance of bone marrow testing in severely immunocompromised HIV patients.

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First case of fungemia caused by a rare and pan-echinocandin resistant yeast Sporopachydermia lactativora in China

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A 37-year-old woman with leukemia developed a rare blood infection caused by a yeast called Sporopachydermia lactativora, which had never been documented to cause bloodstream infection in China before. This yeast is naturally resistant to a common class of antifungal drugs called echinocandins, making it particularly challenging to treat. However, the patient responded well to a different antifungal medication called voriconazole and fully recovered. The researchers suggest that this unusual yeast should be monitored in hospitals as it could become a more common infection in vulnerable patients.

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The Role of AFB1, OTA, TCNs, and Patulin in Forensic Sciences: Applications in Autopsy, Criminal Investigations, and Public Health Prevention

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This research examines how dangerous fungal poisons (mycotoxins) found in contaminated food can be detected in deceased individuals during autopsies. These toxins, produced by common molds, can cause serious health problems including liver cancer, kidney disease, and immune system damage. The study proposes procedures for forensic investigators to collect and analyze these toxins from body tissues and fluids to help solve cases involving poisoning or chronic toxin exposure.

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Bibliometric, taxonomic, and medicinal perspectives of Ganoderma neo-japonicum Imazeki: A mini review

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Ganoderma neo-japonicum, known as purple Lingzhi, is a mushroom traditionally used by indigenous communities in Malaysia and other Asian countries to treat various health conditions. This review examines 36 scientific studies published between 1991 and 2021, showing that the mushroom contains special compounds that can fight cancer cells, lower blood sugar, reduce inflammation, and boost immunity. While laboratory studies show promising results, the mushroom still needs more clinical testing in humans before it can be widely used as a medicine.

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When Emerging Fungal Infections Mimic Tuberculosis: First Reported Case of Invasive Emergomyces europaeus Infection in a Man With Immunocompromise Living in France

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A 65-year-old man living in France who received a kidney transplant developed a serious fungal infection caused by Emergomyces europaeus, a rare fungus that initially appeared to be tuberculosis. Doctors used advanced genetic testing to identify the unusual fungus in samples from his lungs and bone marrow. The patient was treated with a combination of antifungal medications, which successfully cleared the infection. This is the first time this particular fungal infection has been documented in France and highlights how emerging infections can mimic more common diseases.

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