Disease: Pancreatic cancer

Comparative Multi-Omics Analysis and Antitumor Activity of Phylloporia crataegi and Phylloporia fontanesiae

Researchers compared two types of medicinal fungi (Phylloporia crataegi and P. fontanesiae) to understand why one is more effective at fighting cancer. Using advanced molecular analysis techniques, they found that P. crataegi contains higher levels of cancer-fighting compounds and activates more genes related to cancer cell death. These findings suggest that these fungi could be promising sources for developing new cancer treatments.

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Mycobiome of Stool, Blood, Thrombus and Vessel Wall in Abdominal Aortic Aneurysm Patients

This study examined fungal communities in blood, stool, and damaged aorta tissues from patients with abdominal aortic aneurysm, a serious condition where the main blood vessel weakens and bulges. Researchers found that healthy blood vessels contain protective fungi called Tomentella, while damaged vessels have high levels of harmful fungi called Malassezia. Interestingly, the fungi found in damaged vessel walls may not come directly from the gut, suggesting they originate from other body parts like the mouth or skin. These findings suggest that controlling fungal communities with targeted antifungal treatments might help prevent or slow aneurysm development.

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Mushroom Bioactive Molecules as Anticancerous Agents: An Overview

Mushrooms contain natural compounds that show promise in fighting cancer by triggering cancer cell death and boosting immune function. Different mushroom species like oyster, shiitake, and button mushrooms contain substances such as beta-glucans and other polysaccharides that have demonstrated anticancer properties in laboratory and animal studies. While these mushroom compounds work through multiple mechanisms including preventing new blood vessel formation to tumors and stopping cancer cell division, more human clinical trials are needed to confirm their effectiveness as cancer treatments.

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