opportunistic fungal infection

In vitro and in vivo efficacy of the antimycobacterial molecule SQ109 against the human pathogenic fungus, Cryptococcus neoformans

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Researchers discovered that SQ109, an antimycobacterial drug, can effectively kill Cryptococcus fungi that cause serious brain infections in people with weakened immune systems. Unlike current treatments, cryptococcal cells don’t easily develop resistance to SQ109, and it works even better when combined with fluconazole. In mouse studies, SQ109 successfully treated cryptococcal infections, suggesting it could be a valuable new treatment option for patients worldwide, especially in resource-limited regions.

Immunomodulatory activity of Pleurotus pulmonarius crude extract to human monocyte against Cryptococcus neoformans

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This research shows that an extract from the Phoenix oyster mushroom (Pleurotus pulmonarius) can boost the body’s immune cells to fight dangerous fungal infections caused by Cryptococcus neoformans. When immune cells are pre-exposed to this mushroom extract and then encounter the fungus, they become more effective at killing it through increased production of immune-signaling molecules and reactive oxygen species. This natural supplement approach offers a promising alternative to traditional antifungal drugs, which often have significant side effects and can lead to drug resistance.

Disease: opportunistic fungal infection

In vitro and in vivo efficacy of the antimycobacterial molecule SQ109 against the human pathogenic fungus, Cryptococcus neoformans

Immunomodulatory activity of Pleurotus pulmonarius crude extract to human monocyte against Cryptococcus neoformans