Disease: Not primary focus

Quantitative Characterization of Gene Regulatory Circuits Associated With Fungal Secondary Metabolism to Discover Novel Natural Products

Scientists developed a special technology using tiny channels and fluorescent markers to understand how fungi control their genes that produce valuable compounds. By precisely measuring how different genes turn on and off in individual fungal cells, they can now predict and control when and how much of useful medicines and other bioactive molecules are made. They successfully used this knowledge to create new pathways that produce novel compounds, including new types of dendrobine molecules never seen before.

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Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates

This research reveals that fungi living in primate guts follow evolutionary patterns similar to their hosts, suggesting these fungi are not just temporary visitors from diet but long-term residents. By comparing gut fungal communities across humans, chimpanzees, gorillas, and other primates, scientists found that closely related species harbor similar fungi. Some fungal species even appear to have evolved alongside their primate hosts over millions of years, indicating deep evolutionary partnerships.

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