nosocomial infections

Antibiofilm activity and bioactive phenolic compounds of ethanol extract from the Hericium erinaceus basidiome

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Researchers tested a lion’s mane mushroom extract for its ability to stop harmful bacteria from forming protective biofilms that make infections harder to treat. The extract showed strong activity against Proteus mirabilis bacteria, reducing biofilm formation by over 78%. The antibiofilm power comes mainly from two phenolic compounds: protocatechuic acid and p-coumaric acid. These findings suggest lion’s mane mushroom could be developed into natural supplements or food preservatives to prevent bacterial contamination.

The Effect of Supplementing Mushroom Growing Substrates on the Bioactive Compounds, Antimicrobial Activity, and Antioxidant Activity of Pleurotus ostreatus

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This study investigated how adding wheat bran to mushroom growing substrates affects oyster mushroom quality and medicinal properties. The researchers found that wheat bran supplementation increased mushroom yield but slightly decreased antioxidant power, while the mushrooms produced antimicrobial compounds effective against various bacteria and fungi. The mushrooms contained beneficial compounds like vitamin E and phenols, suggesting they could be developed as natural alternatives to synthetic antibiotics.

Endophytic fungi isolated from Vietnamese nut grass (Cyperus rotundus L. Cyperaceae) – A promising solution to mitigate the prime phenomenon of antibiotic resistance

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Scientists discovered seven types of fungi living inside nut grass plants that can fight dangerous bacteria, including those resistant to current antibiotics. These fungi showed strong ability to kill drug-resistant staph bacteria and other serious pathogens. The findings suggest that these naturally-occurring fungi could be developed into new antibiotics to treat infections that currently have limited treatment options.

Isolation and identification of Fusarium species from the water systems of ICUs and transplant wards of hospitals and determination of the in vitro susceptibilities of isolates to conventional antifungals

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Researchers found dangerous Fusarium fungal species in water systems of hospital ICU wards in Tehran, Iran. These fungi can spread through water fixtures and pose serious risks to patients with weak immune systems. Testing showed that certain antifungal drugs like posaconazole and voriconazole worked well against these fungi, but other drugs were less effective. The study emphasizes the importance of better water management and safety measures in hospitals to protect vulnerable patients.

Candida auris: Outbreak, surveillance and epidemiological monitoring in Northern Greece

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A dangerous fungus called Candida auris caused an outbreak in hospitals in Northern Greece starting in October 2022. This fungus is particularly concerning because it is resistant to many commonly used antifungal drugs, especially fluconazole. Researchers monitored and tracked the outbreak across multiple hospitals, finding that all cases belonged to the same genetic type (Clade I) and were treatable with certain alternative antifungal medications. The study emphasizes the importance of careful laboratory surveillance and coordinated infection control measures to prevent further spread of this serious infection.

Genetic sequencing of the airborne fungal spectrum and air quality at a public hospital in Mexico City

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Researchers tested the air inside and outside a Mexico City hospital to identify harmful fungi that could make patients sick. Using two different sampling methods, they found 27 different fungal species, including dangerous ones like Aspergillus fumigatus that cause serious infections especially in people with weakened immune systems. The study shows that hospitals need better air monitoring systems to protect vulnerable patients from these airborne infections.

Detection of Multiple Nosocomial Trichosporon asahii Transmission Events via Microsatellite Typing Assay, South America

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Researchers developed a test to identify different strains of a dangerous fungus called Trichosporon asahii that causes serious infections in hospitals. Using this test on samples from South America, they discovered that multiple patients in different hospitals were infected with genetically identical strains, suggesting the fungus was spreading between patients. This typing method is faster and cheaper than other genetic tests, making it useful for hospitals in countries with limited resources to track and control fungal outbreaks.

A Systematic Comparative Study on the Physicochemical Properties, Volatile Compounds, and Biological Activity of Typical Fermented Soy Foods

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This research compared six popular fermented soy foods to understand their unique flavors and health benefits. Scientists found that each food has different flavor chemicals, with natto being distinctive for containing compounds called pyrazines. All six fermented soy foods showed strong antioxidant and antibacterial properties, making them valuable for health promotion. The findings can help food producers improve these traditional foods.

Molecular evidence of Enterocytozoon bieneusi in arid urban landscapes of shiraz cockroaches (Blattodea), Southwest Iran: Implications for urban public health surveillance

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Researchers in Shiraz, Iran found that cockroaches can carry Enterocytozoon bieneusi, a dangerous fungal parasite that causes severe diarrhea in people with weak immune systems. The study collected and tested 378 cockroaches from hospitals and public areas, discovering three positive cases. While the arid climate of Shiraz appears to limit how well these pathogens survive compared to tropical regions, the presence of parasites in hospital cockroaches poses real health risks, especially for vulnerable patients. Better pest control and sanitation in hospitals are essential to prevent spread.

Do farnesol and tyrosol production in Candidozyma auris biofilms reflect virulence potential?

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Researchers discovered that a dangerous fungus called Candidozyma auris produces signaling molecules called farnesol and tyrosol in biofilms. These molecules appear to be linked to how dangerous the fungus is—strains that produce more of these molecules were more virulent in infection studies. Understanding these signaling molecules could help develop new strategies to fight this drug-resistant pathogen.

Disease: nosocomial infections