Disease: Neuropathic pain

Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity

mycolabadmin

This review examines how psilocybin, the active compound in certain mushrooms, may help treat depression and anxiety by reducing brain inflammation and promoting healthy neurotransmitter function. Both full doses under medical supervision and smaller ‘microdoses’ show promise for mental health conditions. The research suggests psilocybin works by calming the immune system’s inflammatory response while simultaneously supporting the brain’s natural healing and adaptation processes, offering a potential alternative treatment when standard medications don’t work.

Read More »

Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain

mycolabadmin

Researchers found that psilocybin, the active ingredient in magic mushrooms, significantly reduced chronic pain in mice through activation of specific serotonin receptors. The effects lasted for up to two weeks after a single dose, suggesting lasting changes in how the nervous system processes pain. This study suggests psilocybin could be a promising new treatment for chronic pain conditions like neuropathy and inflammation.

Read More »

Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies

mycolabadmin

Chronic pain affects millions of people and is often resistant to current treatments. This paper suggests that chronic pain emerges from interconnected biological, psychological, and social factors working together as a complex system. The authors propose that psychedelic-assisted therapies could help by breaking rigid thought and behavior patterns that maintain pain, allowing the brain and mind to reorganize in healthier ways, similar to how mindfulness meditation works but potentially more dramatically.

Read More »

Scoping Review: The Role of Psychedelics in the Management of Chronic Pain

mycolabadmin

This review examines how psychedelic drugs like LSD and psilocybin might help treat chronic pain conditions such as cluster headaches and phantom limb pain. The researchers found nine studies suggesting these substances could reduce pain by affecting serotonin receptors in the brain. While early results are promising, more rigorous clinical trials are needed before these drugs can become standard pain treatments. The authors note that strict legal restrictions on psychedelics currently limit research opportunities.

Read More »

Application of Medicinal Mushrooms for the Treatment of Peripheral Nerve Injury: A Systematic Review

mycolabadmin

This review examined whether medicinal mushrooms can help repair nerve injuries that often cause pain and disability. Researchers found that four types of mushrooms—particularly Lion’s Mane (Hericium erinaceus)—contain natural compounds that promote nerve healing and regeneration. These mushrooms appear to work by activating specific cellular pathways that help nerve cells survive and regrow. While animal studies show promising results, human clinical trials are needed before these mushroom-based treatments can be recommended for nerve injury patients.

Read More »

Rac1/PAK1 signaling contributes to bone cancer pain by regulation dendritic spine remodeling in rats

mycolabadmin

Researchers studied how bone cancer pain develops in rats and found that a specific cellular signaling pathway called Rac1/PAK1 plays a key role. When tumors grow in bone, this pathway becomes overactive and causes changes in nerve cell structures called dendritic spines, which leads to increased pain sensitivity. By blocking this pathway with a drug called NSC23766, scientists were able to reduce pain and reverse the harmful changes to nerve cells, suggesting a new potential treatment approach for cancer patients suffering from bone pain.

Read More »
Scroll to Top